| basic FUNCTION
| acting as a terminal transducer of TERF1 telomere length control |
|
playing a role in disrupting G-quadruplex structures in telomeric DNA, there by allowing proper elongation by telomerase |
|
telomeric single-strand DNA binding protein protecting telomeres from rapid degradation and likely affecting substrate access to telomerase |
|
functioning to mask an ATR-dependent DNA damage checkpoint from the single-stranded overhang |
|
function independently of TERF2 to repress the activation of the ATM and ATR kinases at natural chromosome ends |
|
required to prevent a telomere checkpoint mediated by another such protein, ATR, that is most likely triggered by the G-overhang |
|
regulates telomere length and protects chromosome ends  |
|
ACD and POT1 function as a unit to protect human telomeres, by both positively and negatively regulating telomerase access to telomere DNA |
|
required to hide telomeres from DNA damage surveillance |
|
protects mammalian chromosome ends from the ATR-dependent DNA damage response, regulates telomerase-mediated telomere extension, and limits 5'-end resection at telomere termini |
|
combines the features of murine Pot1a and Pot1b |
|
is required for efficient telomere C-rich strand replication in the absence of WRN |
|
crucial for restraining telomeric resection |
|
With WRN, are required for efficient chromosome segregation |
|
HNRNPA1, DMRT2 and POT1 act in concert to displace RPA1 from telomeric single-stranded DNA after DNA replication, and promote telomere capping to preserve genomic integrity |
|
preferential recruitment of shelterin complex to areas of the telomere where ss- and ds-DNA are in close proximity, such as the 3prime-telomeric overhang, telomeric DNA bubbles and the D-loop at the base of T-loops |
