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FLASH GENE

Symbol

PORCN

contributors: mct - updated : 31-08-2009

HGNC name	porcupine homolog (Drosophila)
HGNC id	17652

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DHOF focal dermal hypoplasia
Location	Xp11.23      Physical location : 48.367.370 - 48.379.202
Synonym name	porcupine
	protein MG61
Synonym symbol(s)	MG61, MGC29687, PORC, PPN,2410004O13Rik
EC.number	2.3.1.-

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	11.83 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022825 13 - 1849 NP_073736 - 450 - 2002 12034504 NM_203473 14 - 1867 NP_982299 - 456 - 2002 12034504 NM_203474 13 - 1743 NP_982300 - 455 - 2002 12034504 NM_203475 14 - 1761 NP_982301 - 461 - 2002 12034504

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   pharynx       highly   salivary gland       highly Reproductive female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

multiple transmembrane domains putatively serving as O-acyltransferasesiple transmembrane domains

HOMOLOGY

interspecies

ortholog to Drosophila Porc

Homologene

FAMILY	membrane-bound acyltransferase family
	porcupine subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	involved in the processing of Wnt (wingless and int homologue) proteins (regulator of Wnt signaling)
	multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family
	might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DHOF

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS