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FLASH GENE
Symbol PORCN contributors: mct - updated : 31-08-2009
HGNC name porcupine homolog (Drosophila)
HGNC id 17652
Corresponding disease
DHOF focal dermal hypoplasia
Location Xp11.23      Physical location : 48.367.370 - 48.379.202
Synonym name
  • porcupine
  • protein MG61
  • Synonym symbol(s) MG61, MGC29687, PORC, PPN,2410004O13Rik
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.83 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1849 - 450 - 2002 12034504
    14 - 1867 - 456 - 2002 12034504
    13 - 1743 - 455 - 2002 12034504
    14 - 1761 - 461 - 2002 12034504
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     pharynx   highly
     salivary gland   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple transmembrane domains putatively serving as O-acyltransferasesiple transmembrane domains
  • HOMOLOGY
    interspecies ortholog to Drosophila Porc
    Homologene
    FAMILY
  • membrane-bound acyltransferase family
  • porcupine subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in the processing of Wnt (wingless and int homologue) proteins (regulator of Wnt signaling)
  • multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family
  • might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DHOF
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS