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FLASH GENE
Symbol POM121 contributors: mct - updated : 29-05- 201
HGNC name POM121 membrane glycoprotein (rat)
HGNC id 19702
Location 7q11.22      Physical location : 72.349.935 - 72.418.837
Synonym name
  • nuclear envelope pore membrane protein POM121 homolog-related
  • nuclear pore membrane protein 121 kDa
  • nuclear envelope pore membrane protein POM 121
  • Synonym symbol(s) KIAA0618, FLJ41820, MGC3792, P145, POM121A, DKFZp586G1822, DKFZp586P2220, FLJ41820
    DNA
    TYPE functioning gene
    STRUCTURE 68.90 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CALN1 7q11 calneuron 1 LOC389514 7 hypothetical gene supported by BC042156; BC051888; NM_018264 LOC389515 7 similar to Shwachman-Bodian-Diamond syndrome protein (CGI-97) POM121 7q11.23 POM121 membrane glycoprotein (rat) WBSCR20C 7q11.23 POM121 membrane glycoprotein (rat) TRIM50C 7 tripartite motif-containing 50C LOC389516 7 hypothetical gene supported by BC002581; NM_012447 LOC389517 7 similar to Williams Beuren syndrome chromosome region 19 GTF2IP1 7q11.23 general transcription factor II, i, pseudogene 1 LOC389518 7 similar to Neutrophil cytosolic factor 1 LOC389519 7 similar to transcription factor GTF2IRD2 LOC389520 7 similar to Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145) WBSCR20A 7q11.23 Williams Beuren syndrome chromosome region 20A TRIM50A 7q11.23 tripartite motif-containing 50A FKBP6 7q11.23 FK506 binding protein 6, 36kDa FZD9 7q11.23 frizzled homolog 9 (Drosophila) BAZ1B 7q11.23 bromodomain adjacent to zinc finger domain, 1B BCL7B 7q11.23 B-cell CLL/lymphoma 7B TBL2 7q11.23 transducin (beta)-like 2 WBSCR14 7q11.23 Williams Beuren syndrome chromosome region 14 WBSCR24 7q11.23 Williams Beuren syndrome chromosome region 24 STX1A 7q11.23 syntaxin 1A (brain) WBSCR18 7q11.23 Williams Beuren syndrome chromosome region 18 WBSCR22 7q11.23 Williams Beuren syndrome chromosome region 22 WBSCR21 7q11.23 Williams Beuren syndrome chromosome region 21 CLDN3 7q11.23 claudin 3 CLDN4 7q11.23 claudin 4 WBSCR27 7q11.23 claudin 4 WBSCR28 7q11.23 Williams-Beuren syndrome critical region 28
    regionally located in the centromeric repeat flanking the WBS1 deletion
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 5997 - 984 - 2007 17900573
  • POM121A
  • exon 4A and 16A
  • - - - - 856 - 2007 17900573
    high homology with the C-terminal portion of rodent Pom121, but its predicted N-terminal sequence shows no homology with Pom121
    - - - - 1229 - 2007 17900573
    an N-terminal hydrophobic transmembrane domain
    - - 7011 - 999 - 2007 17900573
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signals, which bind to importin beta via importin alpha and likely function with RANGTP, play an essential role in targeting POM121 to the interphase nuclear pore complex
  • HOMOLOGY
    interspecies homolog to rattus nuclear envelope pore membrane protein POM121,homolog-related
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope,pore
    text
  • present at new pore assembly sites at a time that coincides with inner nuclear membrane (INM) and outer nuclear membrane (ONM) fusion
  • basic FUNCTION
  • playing a role on maintenance of nuclear pore complex structure/organization
  • vertebrate-specific integral membrane nucleoporin, is indispensable for an early step in interphase nuclear pore complex assembly
  • nuclear migration of POM121 and its subsequent interaction with INM (inner nuclear membrane) proteins are required to initiate interphase NPC assembly
  • SUN1 specifically required for interphase assembly and localized with POM121 at forming pores
  • plays an important role in both modes of assembly and links nuclear membrane formation and expansion to nuclear pore biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component components of the nuclear pore complex (NPC) in vertebrate
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • capture of AT-rich chromatin by AHCTF1 recruits POM121 and NDC1 to initiate nuclear pore assembly
  • interacts with importin alpha/beta and a group of nucleoporins in an NLS-dependent manner
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • POM121 and SUN1 interact transiently to promote early steps of interphase Nuclear pore complexes assembly
  • NPAP1, originating from the vertebrate nucleoporin gene POM121 and--after several steps of retrotransposition and duplication-has been subjected to genomic imprinting and positive selection after integration into the imprinted SNRPN-UBE3A chromosomal domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS