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FLASH GENE
Symbol POLRMT contributors: mct - updated : 28-03-2014
HGNC name polymerase (RNA) mitochondrial (DNA directed)
HGNC id 9200
Location 19p13.3      Physical location : 617.222 - 633.568
Synonym name mitochondrial DNA-directed RNA polymerase
Synonym symbol(s) APOLMT, MTRPOL, RPOM, MTRNAP, h-mtRPOL
EC.number 2.7.7.6
DNA
TYPE functioning gene
STRUCTURE 16.34 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D17S791 - D17S797 - D17S1795 - ITGA3 - D17S788 - D17S790 - HLF HLF - D17S1607 - MPO - D17S792 - POLRMT - D17S808 - D17S794 - cen
Physical map
LOC390871 19 similar to CXYorf1-related protein LOC390872 19 similar to Olfactory receptor 4F3 LOC388486 19 similar to bA476I15.3 (novel protein similar to septin) LOC390873 19 similar to capicua homolog LOC388487 19 LOC388487 PPAP2C 19p13 phosphatidic acid phosphatase type 2C KIAA1193 19p13.3 phosphatidic acid phosphatase type 2C THEG 19p13.3 Theg homolog (mouse) KIAA1957 19p13.3 KIAA1957 FLJ40059 19p13.3 hypothetical protein FLJ40059 MADCAM1 19p13.3 mucosal vascular addressin cell adhesion molecule 1 LOC91978 19p13.3 hypothetical gene supported by BC009520 CDC34 19p13.3 cell division cycle 34 GZMM 19p13.3 granzyme M (lymphocyte met-ase 1) BSG 19p13.3 basigin (OK blood group) HCN2 19p13.3 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 POLRMT 19p13.3 polymerase (RNA) mitochondrial (DNA directed) FGF22 19p13.3 fibroblast growth factor 22 RNF126 19p13.3 ring finger protein 126 FSTL3 19p13 follistatin-like 3 (secreted glycoprotein) PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3800 - 1230 - 1997 9097968
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousnervecranial nerve  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY phage and mitochondrial RNA polymerase family
CATEGORY enzyme , DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • may be part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation and/or ribosome biogenesis during human mitochondrial gene expression
  • primase required for initiation of DNA synthesis from the light-strand origin of DNA replication
  • can function as an origin-specific primase in mammalian mitochondria
  • serves as both the transcriptase for expression and the primase for replication of mitochondrial DNA
  • requires the factors TFAM and TFB2M for binding and melting promoter DNA
  • early phage-like POLRMT lost functions in promoter binding and melting, which were provided by initiation factors in trans during evolution, to enable mitochondrial gene regulation and the adaptation of mitochondrial function to changes in the environment
  • organization of TFAM, POLRMT and TFB2M around thelight-strand promoter (LSP), represent the first structural characterization of the entire mitochondrial transcriptional initiation complex
  • TFAM first recruits POLRMT to the promoter, followed by TFB2M binding and induction of promoter melting
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • POLRMT/TFB2M heterodimer is unable to interact with promoter elements and initiate even abortive transcription in the absence of TFAM
  • TFB2M along with two other proteins, POLRMT and TFAM, are key components of the core mitochondrial transcription apparatus
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TFB2M (heterodimer is unable to interact with promoter elements and initiate even abortive transcription in the absence of TFAM)
  • interacting with MRPL12
  • TEFM interacts with the catalytic region of POLRMT
  • MRPL12 interacts with TFB2M and POLRMT (MRPL12 and TFB2M bind POLRMT in distinct protein complexes)
  • POLRMT needs both TFB2M and TFAM to melt the promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS