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FLASH GENE
Symbol POLR2K contributors: npt/ - updated : 28-11-2007
HGNC name polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
HGNC id 9198
Location 8q22.2      Physical location : 101.162.838 - 101.166.229
Synonym name
  • DNA directed RNA polymerase II polypeptide K
  • RNA polymerases I, II, and III subunit ABC4
  • Synonym symbol(s) RPB7.0, RPB10A, RPB12, RPCX, RPABC4, RPB10alpha
    EC.number 2.7.7.6
    DNA
    TYPE functioning gene
    STRUCTURE 3.39 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1 FLJ13955 8q22.2 hypothetical protein FLJ13955 KCNS2 8q23.3-q24.11 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 STK3 8q22.2 serine/threonine kinase 3 (STE20 homolog, yeast) MRP63P7 8q22.2 mitochondrial ribosomal protein 63 pseudogene 7 OSR2 8q22.2 odd-skipped-related 2A protein COH1 8q22.2 Cohen syndrome 1 COX6C 8q22-q23 cytochrome c oxidase subunit VIc DKFZP434I092 8q22.3 DKFZP434I092 protein LOC286151 8q22.3 similar to RIKEN cDNA 4930533G20 POLR2K 8q22 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa SPAG1 8q22 sperm associated antigen 1 RNF19 8q22 ring finger protein 19 LOC157567 8q22.3 hypothetical protein LOC157567 MGC39715 8q22.3 hypothetical protein MGC39715 PABPC1 8q22.2-q23 poly(A) binding protein, cytoplasmic 1 LOC392256 YWHAZ 2p25.2-p25.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide LOC51123 8q22.3 HSPC038 protein FKSG17 8q22.3 HSPC038 protein TFCP2L3 8q22.3 HSPC038 protein NCALD 8q22-q23 neurocalcin delta LOC392257 8 similar to IAP-associated factor VIAF1; phosducin-like 2 RRM2B 8q23.1 ribonucleotide reductase M2 B (TP53 inducible) DD5 8q22 ribonucleotide reductase M2 B (TP53 inducible) ODF1 8q22.3 outer dense fiber of sperm tails 1 TIEG 8q22.2 TGFB inducible early growth response OAZIN 8q22.3 ornithine decarboxylase antizyme inhibitor LOC389679 8 similar to hypothetical protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 971 6.9 58 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid    
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text primitive neurectoderm
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly conserved sequence in C terminal half with an invariant motif corresponding to a canonical zinc binding domain
  • HOMOLOGY
    interspecies homolog to Sc10 alpha
    Homologene
    FAMILY
  • archaeal rpoP/eukaryotic RPC10 RNA polymerase subunit family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of RNA polymerase II and may be of POLRI and POLRIII
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS