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FLASH GENE
Symbol POLR2H contributors: - updated : 05-07-2005
HGNC name polymerase (RNA) II (DNA directed) polypeptide H
HGNC id 9195
Location 3q28      Physical location : 184.081.193 - 184.086.363
Synonym symbol(s) RPB8, RPB17, RPABC3, hsRPB8
EC.number 2.7.7.6
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  predominantly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix moderately
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Polr2h
homolog to yeast RPB8
Homologene
FAMILY
CATEGORY enzyme , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • shared by all 3 RNA polymerases
  • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • NFKBIB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS