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FLASH GENE
Symbol POLR2F contributors: - updated : 02-09-2006
HGNC name polymerase (RNA) II (DNA directed) polypeptide F
HGNC id 9193
Location 22q13.1      Physical location : 38.349.673 - 38.365.318
Synonym name DNA directed RNA polymerase II 14.4 kda polypeptide
Synonym symbol(s) HRBP14.4, RPABC2, RPB6, hRPB14.4, hsRPB6
EC.number 2.7.7.6
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP LGALS1 22q13.1 lectin, galactoside-binding, soluble, 1 (galectin 1) MGC3731 22q13.1 hypothetical protein MGC3731 HRIHFB2122 22q13.1 hypothetical protein MGC3731 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13 C22orf23 22q13.1 chromosome 22 open reading frame 23 POLR2F 22q13.1 polymerase (RNA) II (DNA directed) polypeptide F SOX10 22q13.1 SRY (sex determining region Y)-box 10 LOC388899 22 LOC388899 PRKCABP 22q13.1 protein kinase C, alpha binding protein SLC16A8 22q12.3-q13.2 solute carrier 16 (monocarboxylic acid transporters), member 8 FLJ22582 22q13.1 hypothetical protein FLJ22582 PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Nervousbrain   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY eukaryotic RPB6 RNA polymerase subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA, that is also shared by the other two DNA-directed RNA polymerases
  • catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS