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FLASH GENE

Symbol

POLR2E

contributors: mct - updated : 27-10-2011

HGNC name	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
HGNC id	9192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 1.086.579 - 1.095.391
Synonym name	DNA directed RNA polymerase II polypeptide E
Synonym symbol(s)	RPABC1, RPB5, XAP4, hRPB25, hsRPB5
EC.number	2.7.7.6

DNA

TYPE	functioning gene
STRUCTURE	8.81 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002695 8 - 2866 - 210 - 2011 21310960

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Skin/Tegument skin       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

RPB5 RNA polymerase subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION

catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

CELLULAR PROCESS

nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding C19orf2
	hepatitis B virus X protein (HBx), a protein known to be a causative agent in the formation of hepatocellular carcinoma interacts directly with POLR2E

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS