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FLASH GENE
Symbol POLR1B contributors: KTN/npt - updated : 07-01-2008
HGNC name polymerase (RNA) I polypeptide B, 128kDa
HGNC id 20454
Location 2q13      Physical location : 113.299.491 - 113.334.727
Synonym name
  • DNA-directed RNA polymerase I subunit RPA2
  • RNA polymerase I subunit 2
  • Synonym symbol(s) RPA135, RPO1-2, FLJ10816, FLJ21921, MGC131780
    EC.number 2.7.7.6
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC391426 2 similar to ENSANGP00000004103 ANAPC1 2q12.1 anaphase-promoting complex 1 (meiotic checkpoint regulator) MERTK 2q14.1 c-mer proto-oncogene tyrosine kinase FLJ14681 2q13 hypothetical protein FLJ14681 FLJ37440 2q13 hypothetical protein FLJ37440 LOC84524 2q13 zinc finger protein FLJ41410 2q13 FLJ41410 protein LOC389020 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 TTL 2q13 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 POLR1B 2q13 polymerase (RNA)1polypeptide B, 128kDa C2orf9 2q13 chromosome 2 open reading frame 9 SLC20A1 2q11-q14 solute carrier family 20 (phosphate transporter), member 1 FLJ40629 2q14.1 hypothetical protein FLJ40629 IL1A 2q13 interleukin 1, alpha IL1B 2q13 interleukin 1, beta IL1F7 2q12.1-q14.1 interleukin 1 family, member 7 (zeta) IL1F9 2q13 interleukin 1 family, member 9 IL1F6 2q12-q14.1 interleukin 1 family, member 6 (epsilon) IL1F8 2q12-q14.1 interleukin 1 family, member 8 (eta) IL1F5 2q12.1 interleukin 1 family, member 5 (delta) IL1F10 2q12 interleukin 1 family, member 10 (theta) IL1RN 2q13-q14.2 interleukin 1 receptor antagonist TIC 2q13 interleukin 1 receptor antagonist PAX8 2q12-q14 paired box gene 8 LOC391427 2 similar to Ig kappa chain precursor V region (orphon V108) - human  (fragment) CBWD2 2q13 COBW domain containing 2 FOXD4L1 2q13 COBW domain containing 2 LOC284964 2q14.1 similar to bA395L14.5 (novel phosphoglucomutase like protein) LOC389021 2 hypothetical gene supported by BC063555 MGC13005 2q14.1 hypothetical protein MGC13005 RPL23AP7 2q14 ribosomal protein L23a pseudogene 7 RABL2A 2q13 RAB, member of RAS oncogene family-like 2A bA395L14.12 2q14.1 u2 small nuclear ribonucleoprotein polypeptide A' pseudogene bA395L14.13 2q14.1 acrosin-like protease
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 5968 128 1135 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly
    Respiratoryrespiratory tracttrachea  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Muscular   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C4 type zinc finger
  • HOMOLOGY
    interspecies homolog to chimpanzee POLR1B (99.6 pc)
    homolog to rattus Rpo1-2 (90.8 pc)
    homolog to murine Rpo1-2 (89.7 pc)
    Homologene
    FAMILY
  • RNA polymerase beta chain family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • proposed to contribute to the polymerase catalytic activity and forming the polymerase active center together with the largest subunit
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
  • biosynthesis of rRNA
  • a component
  • component of the multisubunit complex of eukaryotic nuclear DNA directed RNA polymerase producing ribosomal RNA, brought to ribosomal genes as a distinct subunit
  • second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS