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FLASH GENE
Symbol POLM contributors: - updated : 26-05-2006
HGNC name polymerase (DNA directed), mu
HGNC id 9185
Location 7p13      Physical location : 44.111.848 - 44.122.129
Synonym symbol(s) POL-IOTA,TDT-N
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HIP-55 7p13 src homology 3 domain-containing protein HIP-55 LOC393058 7 similar to OG-2 homeodomain protein-like; similar to U65067 (PID:g1575526) PGAM2 7p13-p12 phosphoglycerate mutase 2 (muscle) POLM 7p13 polymerase (DNA directed), mu LOC393059 7 similar to peptidyl-Pro cis trans isomerase AEBP1 7p15.1 AE binding protein 1 TPK1 7q34 thiamin pyrophosphokinase 1 POLD2 7p15.1 polymerase (DNA directed), delta 2, regulatory subunit 50kDa BLVRA 7p14-cen biliverdin reductase A MYL7 7p21-p11.2 myosin, light polypeptide 7, regulatory GCK 7p14-p13 glucokinase (hexokinase 4, maturity onset diabetes of the young 2) YKT6 7p15.1 SNARE protein Ykt6 CAMK2B 7p13 calcium/calmodulin-dependent protein kinase (CaM kinase) II beta MRPS24 7p14 mitochondrial ribosomal protein S24 URG4 7p13 up-regulated gene 4 LOC51619 7p13 ubiquitin-conjugating enzyme HBUCE1 LOC389486 7 similar to RAS p21 protein activator 4; GTPase activating protein-like; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator WBSCR19 7q11.23 Williams Beuren syndrome chromosome region 19 KIAA1068 7p13-p12 Williams Beuren syndrome chromosome region 19 LOC392023 7 similar to RasGAP-activating-like protein 2 (Calcium-promoted Ras inactivator) HIP-55 7p13 src homology 3 domain-containing protein HIP-55 PGAM2 7p13-p12 phosphoglycerate mutase 2 (muscle) POLM 7p13 polymerase (DNA directed), mu AEBP1 7p15.1 AE binding protein 1 POLD2 7p15.1 polymerase (DNA directed), delta 2, regulatory subunit 50kDa MYL7 7p21-p11.2 myosin, light polypeptide 7, regulatory NPC1L1 7p13 NPC1 (Niemann-Pick disease, type C1, gene)-like 1 GCK 7p14-p13 glucokinase (hexokinase 4, maturity onset diabetes of the young 2) DDX56 7p13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 YKT6 7p15.1 SNARE protein Ykt6 HNLF 7p13 putative NFkB activating protein HNLF CAMK2B 7p13 calcium/calmodulin-dependent protein kinase (CaM kinase) II beta OGDH 7p14-p13 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) LOC393060 7 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) LOC393061 7 similar to ribosomal protein L7
RNA
TRANSCRIPTS type messenger
text unusually large number of splice variants - Aoufouchi
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
BRCT domain,an helix-loop-helix (HLH) DNA-binding motif and a POLX domain
HOMOLOGY
interspecies homolog to murine Polm (DNA polymerase mu);
intraspecies homolog to NTT (deoxynucleotilyltransferase)
Homologene
FAMILY POLX family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • putative mutator polymerase involved in somatic hypermutation of Ig genes
  • involved in the non homologous end-joining pathway for repair of double-strand breaks
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a stable complex with XRCC4-ligase 4 and recruiting it to Ku (G22P1 - XRCC5 - PRKOC) to the DNA ends
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS