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FLASH GENE
Symbol POLL contributors: - updated : 26-05-2006
HGNC name polymerase (DNA directed), lambda
HGNC id 9184
Location 10q23      Physical location : 103.338.638 - 103.348.027
Synonym name DNA polymerase kappa (DNA polymerase beta-N)
Synonym symbol(s) RP11-529I10.1, BETA-N, POL-KAPPA
EC.number 2.7.7.7
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209 BA108L7.2 10q24.32 similar to rat tricarboxylate carrier-like protein FKSG28 10q24.32 hypothetical protein FKSG28 C10orf1 10q24 chromosome 10 open reading frame 1 TLX1 10q24 T-cell leukemia, homeobox 1 LBX1 10q24 transcription factor similar to D. melanogaster homeodomain protein lady bird late BTRC 10q24-q25 beta-transducin repeat containing POLL 10q23 polymerase (DNA directed), lambda DKFZP566F084 SHFM3 10q24 split hand/foot malformation (ectrodactyly) type 3 FGF8 10q24 fibroblast growth factor 8 (androgen-induced) NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase) KCNIP2 10q24 Kv channel interacting protein 2 FLJ13114 10q24.32 hypothetical protein FLJ13114 HPS6 10q24.32 hypothetical protein FLJ13114 LDB1 10q24-q25 LIM domain binding 1 PRC 10q24.32 PGC-1 related co-activator NOLC1 10q22-q25 nucleolar and coiled-body phosphoprotein 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BRCT domain
  • an helix-loop-helix (HLH) DNA-binding motif
  • a POLX domain
  • HOMOLOGY
    intraspecies homolog to POLB
    Homologene
    FAMILY POLX family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • potentially involved in DNA repair synthesis associated with meiosis
  • having functions in DNA polymerization events during non-homologous end joining
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with XRCC4-ligase IV complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS