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FLASH GENE
Symbol POLK contributors: - updated : 27-09-2004
HGNC name polymerase (DNA directed) kappa
HGNC id 9183
Location 5q13      Physical location : 74.807.656 - 74.895.644
Synonym name DinB (E. coli) homolog 1 (yeast RAD30 related)
Synonym symbol(s) DINB1, DINP, POLQ
DNA
TYPE functioning gene
STRUCTURE 87.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • from the N terminus,five highly conserved motifs, I, II, III likely involved in DNA binding and nucleotidyltransferase activities, IV and V representing the helix-hairpin-helix motif
  • two zinc finger domains of C2H2 type in the C terminal region
  • HOMOLOGY
    interspecies homolog to E.coli Din B
    intraspecies homolog to RAD30 related
    Homologene
    FAMILY member of the UmuC/DinB superfamily of by pass DNA polymerase
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • DNA polymerase IV, facilitating the replication of templates containing abnormal bases of possessing structurally aberrant replication forks inhibitinh normal DNA synthesis
  • unable to by pass a TT dimer non abasic site
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS