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FLASH GENE
Symbol POLI contributors: npt/ - updated : 03-10-2006
HGNC name polymerase (DNA directed) iota
HGNC id 9182
Location 18q21.1      Physical location : 51.795.848 - 51.824.602
Synonym name
  • RAD30 homolog B
  • RAD30 (S. cerevisiae) homolog B
  • Synonym symbol(s) RAD30B, RAD3OB, Eta2
    EC.number 2.7.7.7
    DNA
    TYPE functioning gene
    STRUCTURE 28.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D18S474 - D18S1119 - POLI - FECH - NEDD4L - D18S64 - qter
    Authors GeneMap (99)
    Physical map
    MYO5B 18q12 myosin VB FLJ32743 18q21.1 hypothetical protein FLJ32743 MBD1 18q21 methyl-CpG binding domain protein 1 CGBP 18q12 methyl-CpG binding domain protein 1 MGC10200 18q21.1 hypothetical protein MGC:10200 LOC390853 18 similar to acidic ribosomal phosphoprotein P0 MAPK4 18q21.2-q21.3 mitogen-activated protein kinase 4 B29 18q21 mitogen-activated protein kinase 4 ME2 18q21 malic enzyme 2, NAD(+)-dependent, mitochondrial ELAC1 18q21 elaC homolog 1 (E. coli) MADH4 18q21.1 MAD, mothers against decapentaplegic homolog 4 (Drosophila) LOC51320 18q21.1 hypothetical protein LOC51320 LOC390854 18 similar to neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); Rho guanine nucleotide exchange factor (GEF) 8 LOC390855 18 similar to 40S ribosomal protein S8 DCC 18q21.1 deleted in colorectal carcinoma LOC390856 18 similar to ribosomal protein L29 MBD2 18q21.1 methyl-CpG binding domain protein 2 POLI 18q21.1 polymerase (DNA directed) iota STARD6 18q21.2 START domain containing 6 MGC33382 18q21.2 hypothetical protein MGC33382 FLJ39106 18q21.2 hypothetical protein FLJ39106 LOC390857 18 similar to protein 40kD RAB27B 18q12.3-q21 RAB27B, member RAS oncogene family SE57-1 18q21 CTCL tumor antigen se57-1 TCF4 18q21.1 transcription factor 4 TXNL 18q21.2 thioredoxin-like, 32kDa WDR7 18q21.1-q22 WD repeat domain 7 MGC33608 18q21.31 hypothetical protein MGC33608 SIAT8C 18q21.2 sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase) ONECUT2 18q21.1-q21.2 one cut domain, family member 2 FECH 18q21.2 ferrochelatase (protoporphyria) NARS 18q21.2-q21.3 asparaginyl-tRNA synthetase ATP8B1 18q21 ATPase, Class I, type 8B, member 1 LOC284288 18q21.31 similar to Ribosomal protein L24-like LOC388476 18 similar to Nonhistone chromosomal protein HMG-14 (High-mobility group nucleosome binding domain 1) NEDD4L 18q21.2 neural precursor cell expressed, developmentally down-regulated 4-like HAK 18q21.31-q21.32 heart alpha-kinase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6074 82.9 740 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus    
    Nervousspinal cord    
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage predominantly, in postmeiotic round spermatids
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD30,B
    Homologene
    FAMILY
  • DNA polymerase type-Y family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • low fidelity and error prone, DNA polymerase promoting replication by incorporation deoxynucleotides opposite and bypassing DNA lesions, inducing somatic hypermutation in immunoglobulin genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS