basic FUNCTION
| polymerase eta, error free replicator, also capable of error prone translesion DNA synthesis in vitro |
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a thymine dimer bypass DNA polymerase activity |
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post replication repair |
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limiting factor for A:T mutations and contributes to the efficient diversification of Ig genes and affinity maturation of antibodies |
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normally required for accurate translesion DNA synthesis (TLS) past UV-induced cyclobutane pyrimidine dimers |
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recruited to sites of replication arrest in a tightly regulated process through interaction with PCNA |
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plays an important role in preventing genome instability after UV- and cisplatin-induced DNA damage |
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DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers |
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action on ultraviolet-damaged DNA crucial in suppressing the mutagenic and carcinogenic consequences of sun exposure, thereby reducing the incidence of skin cancers in humans |
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acts like a ‘molecular splint’ to stabilize damaged DNA in a normal B-form conformation |
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novel non-catalytic role for POLH in promoting PCNA monoubiquitination |