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FLASH GENE
Symbol POLE3 contributors: - updated : 27-08-2005
HGNC name polymerase (DNA directed), epsilon 3 (p17 subunit)
HGNC id 13546
Location 9q33      Physical location : 116.169.517 - 116.173.029
Synonym name histone fold protein CHRAC17
Synonym symbol(s) CHRAC17, YBL1 ,P17
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
histone fold domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to murine Pole3
Homologene
FAMILY
  • histone fold superfamily
  • H2A-H2B subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in heterochromatin dynamics
  • important for cell viability,developmental gene expression and chromosome structure
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, replication
    nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the human ISWI chromatin remodelling complex with ACF1 and an other histone-fold protein CHRAC1
  • INTERACTION
    DNA binding to naked DNA
    RNA
    small molecule
    protein CHRAC1,ACF1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS