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FLASH GENE

Symbol

POLE3

contributors: - updated : 27-08-2005

HGNC name	polymerase (DNA directed), epsilon 3 (p17 subunit)
HGNC id	13546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q33      Physical location : 116.169.517 - 116.173.029
Synonym name	histone fold protein CHRAC17
Synonym symbol(s)	CHRAC17, YBL1 ,P17

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

histone fold domains

mono polymer

heteromer , complex

HOMOLOGY

interspecies

homolog to murine Pole3

Homologene

FAMILY	histone fold superfamily
	H2A-H2B subfamily

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	playing a role in heterochromatin dynamics
	important for cell viability,developmental gene expression and chromosome structure

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, replication
	nucleotide, repair
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the human ISWI chromatin remodelling complex with ACF1 and an other histone-fold protein CHRAC1

INTERACTION

DNA	binding to naked DNA

RNA

small molecule

protein

CHRAC1,ACF1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS