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FLASH GENE
Symbol POLD4 contributors: mct/npt - updated : 05/01/2009
HGNC name polymerase (DNA-directed), delta 4
HGNC id 14106
Location 11q13.2      Physical location : 67.119.020 - 67.121.052
Synonym name DNA polymerase delta smallest subunit p12
Synonym symbol(s) p12, POLDS
EC.number 2.7.7.7
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC254439 11q13.1 hypothetical gene supported by AK026328 SYT12 11q12.2 synaptotagmin XII ARHD 11q14.3 ras homolog gene family, member D FBXL11 11q12.2 F-box and leucine-rich repeat protein 11 PRO1880 11q13.2-q13.4 F-box and leucine-rich repeat protein 11 ADRBK1 11q13.3 adrenergic, beta, receptor kinase 1 LOC338692 11q13.1 hypothetical protein LOC338692 SSH-3 11q13.1 slingshot 3 POLD4 11q13 polymerase (DNA-directed), delta 4 CLC 19q13.1 Charot-Leyden crystal protein RAD9A 11q13.1-q13.2 RAD9 homolog (S. pombe) PPP1CA 11q13.3 protein phosphatase 1, catalytic subunit, alpha isoform RPS6KB2 11q13.3 ribosomal protein S6 kinase, 70kDa, polypeptide 2 FLJ00332 11q13.1 FLJ00332 protein KIAA1394 11q13.1 KIAA1394 protein PTPRCAP 11q13 protein tyrosine phosphatase, receptor type, C-associated protein CORO1B 11q12.2 coronin, actin-binding protein, 1B LOC390212 11 similar to putative G-protein coupled receptor CABP4 11q13.1-q13.4 calcium binding protein 4 FLJ21749 11q13.1 hypothetical protein FLJ21749 AIP 11q13.3 aryl hydrocarbon receptor interacting protein PITPNM1 11q13 phosphatidylinositol transfer protein, membrane-associated 1 DOC-1R 11q13 tumor suppressor deleted in oral cancer-related 1 CABP2 11q13.1 calcium binding protein 2 GSTP1 11q13.3 glutathione S-transferase pi FLJ90834 11q13.1 hypothetical protein FLJ90834 NDUFV1 11q13 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 981 12.3 107 - Huang (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   moderately
 parathyroid   moderately
Lymphoid/Immunetonsils   predominantly
Reproductivefemale systemovary  moderately
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to S. pombe Cdm1
homolog to rattus Pold4 (82.2 pc)
homolog to murine Pold4 (82.2 pc)
Homologene
FAMILY
  • DNA polymerase delta subunit 4 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • required for optimal DNA polymerase delta activity
  • may contribute to PCNA-dependent activity of DNA polymerase delta
  • could play a role in stabilizing the overall pol delta-PCNA complex as well as pol delta itself
  • having functions in cell proliferation and maintenance of genomic stability of human cells (Huang 2010)
  • required for maintaining the proper nuclear structures suggesting that the pathological structures reflect elevated DNA damage in chromosomes (Huang 2010)
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    PHYSIOLOGICAL PROCESS
    text positive regulation of endothelial cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of DNA polymerase delta
  • heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa
  • ubiquitinated
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with WRNIP1
  • binds to POLD1, POLD2, and an accessory protein of PCNA, which allows pol delta to exhibit its full activity (Huang 2010)
  • interacting with BLM
  • cell & other
    REGULATION
    Other rapid degradation, regulated by ATR, occurred in response to UV or genotoxic treatment of HeLa and HEK293T cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS