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FLASH GENE
Symbol POLD3 contributors: mct/npt - updated : 23-01-2019
HGNC name polymerase (DNA-directed), delta 3, accessory subunit
HGNC id 20932
Location 11q13.4      Physical location : 74.303.628 - 74.353.765
Synonym name
  • polymerase (DNA-directed), delta 3
  • DNA polymerase subunit delta p66
    • Synonym symbol(s) KIAA0039, p66, p68, MGC119642, MGC119643
    EC.number 2.7.7.7
    DNA
    TYPE functioning gene
    STRUCTURE 50.14 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3430 51.3 466 - Masuda (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline-rich domain
  • a bipartite nuclear localization signal (NLS)
  • a highly conserved region between AAs 384 and 399 in the C-terminus phosphorylated, most probably by Protein kinase CK2, and another region, most probably located within the PCNA interacting domain in its extreme C-terminus, regulates its interaction with PCNA (Lemmens 2008)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to yeast S.pombe Cdc27
    Homologene
    FAMILY
  • polymerase delta family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polymerase (DNA directed) delta 3, accessory subunit
  • mainly mediate polymerase interaction with PCNA, an auxiliary factor that greatly enhances DNA polymerase delta processivity on primed DNA templates (Lemmens 2008)
  • concurrent phosphorylation events may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle (Lemmens 2008)
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text nuclear genome
    PATHWAY
    metabolism
    signaling
    a component
  • also complexing with DNA ligase 1
  • heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa, and 12 kDa
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to PCNA (POLD3 plays a crucial role in the efficient recycling of PCNA during dissociation-association cycles of pol delta) (Masuda 2007)
  • negatively regulates error-prone translesion synthesis that is dependent on POLD3, the accessory subunit of the replicative DNA polymerase Pol delta
  • mitotic DNA synthesis, termed MiDAS, requires the MUS81-EME1 endonuclease and a non-catalytic subunit of the Pol-delta complex, POLD3
    • cell & other
    REGULATION
    Other modified by ubiquitin and SUMO3 (Liu 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colorectal cancer
    Variant & Polymorphism
  • rs3824999, intronic to POLD3 influences colorectal cancer risk
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS