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FLASH GENE
Symbol POLD3 contributors: mct/npt - updated : 23-01-2019
HGNC name polymerase (DNA-directed), delta 3, accessory subunit
HGNC id 20932
Location 11q13.4      Physical location : 74.303.628 - 74.353.765
Synonym name
  • polymerase (DNA-directed), delta 3
  • DNA polymerase subunit delta p66
    • Synonym symbol(s) KIAA0039, p66, p68, MGC119642, MGC119643
    EC.number 2.7.7.7
    DNA
    TYPE functioning gene
    STRUCTURE 50.14 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3430 51.3 466 - Masuda (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline-rich domain
  • a bipartite nuclear localization signal (NLS)
  • a highly conserved region between AAs 384 and 399 in the C-terminus phosphorylated, most probably by Protein kinase CK2, and another region, most probably located within the PCNA interacting domain in its extreme C-terminus, regulates its interaction with PCNA (Lemmens 2008)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to yeast S.pombe Cdc27
    Homologene
    FAMILY
  • polymerase delta family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polymerase (DNA directed) delta 3, accessory subunit
  • mainly mediate polymerase interaction with PCNA, an auxiliary factor that greatly enhances DNA polymerase delta processivity on primed DNA templates (Lemmens 2008)
  • concurrent phosphorylation events may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle (Lemmens 2008)
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text nuclear genome
    PATHWAY
    metabolism
    signaling
    a component
  • also complexing with DNA ligase 1
  • heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa, and 12 kDa
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to PCNA (POLD3 plays a crucial role in the efficient recycling of PCNA during dissociation-association cycles of pol delta) (Masuda 2007)
  • negatively regulates error-prone translesion synthesis that is dependent on POLD3, the accessory subunit of the replicative DNA polymerase Pol delta
  • mitotic DNA synthesis, termed MiDAS, requires the MUS81-EME1 endonuclease and a non-catalytic subunit of the Pol-delta complex, POLD3
    • cell & other
    REGULATION
    Other modified by ubiquitin and SUMO3 (Liu 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colorectal cancer
    Variant & Polymorphism
  • rs3824999, intronic to POLD3 influences colorectal cancer risk
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS