Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

POLB

contributors: mct/npt - updated : 03-02-2015

HGNC name	polymerase (DNA directed), beta
HGNC id	9174

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p11.21      Physical location : 42.196.029 - 42.229.313
Synonym name	DNA pol beta
Synonym symbol(s)	MGC125976
EC.number	2.7.7.7

DNA

TYPE	functioning gene
STRUCTURE	33.28 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D8S87 - D8S135 - D8S255 - D8S268 /ANK1 - POLB /PLAT PLAT - cen - D8S531 /D8S519 - D8S517 /D8S538 - D8S524 - qter
Authors	SCW8-1 (94)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002690 14 - 1259 NP_002681 - 335 - Sellick (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly   thyroid       highly Reproductive female system ovary     highly   male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a Creb1 binding site

HOMOLOGY

Homologene

FAMILY

DNA polymerase type-X family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in DNA repair and synthesis also having a DNA ligase activity
	is required at a very early step in the processing of meiotic DSB
	is required at a very early step in the processing of meiotic DSBs, at or before the removal of SPO11 from DSB ends and the generation of the 3prime single-stranded tails necessary for subsequent strand exchange

CELLULAR PROCESS	cell cycle,division,meiosis
	nucleotide, repair
	nucleotide, transcription, initiation

PHYSIOLOGICAL PROCESS

text	involved in repair of oxidative base lesions

PATHWAY

metabolism

signaling

DNA repair pathways

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with XRCC1 (XRCC1-POLB interaction is important for repair of damage caused by alkylating agents)(Cuneo 2010)
	is critical for the repair of SPO11-induced double-strand breaks (DSBs)
	in response to cellular proliferation and DNA damage, proteasome and HSP90AA1-mediated regulation of POLB and XRCC1 alters the DNA repair complex architecture

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   is an underlying cause of systemic lupus erythematosus (SLE)

Susceptibility

to gastric, colon, prostate carcinoma

Variant & Polymorphism other	variant increasing the risk of carcinoma
	people who carry the rs3136797 germline SNP may be at an increased risk for cancer susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS