Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POLB contributors: mct/npt - updated : 03-02-2015
HGNC name polymerase (DNA directed), beta
HGNC id 9174
Location 8p11.21      Physical location : 42.196.029 - 42.229.313
Synonym name DNA pol beta
Synonym symbol(s) MGC125976
EC.number 2.7.7.7
DNA
TYPE functioning gene
STRUCTURE 33.28 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D8S87 - D8S135 - D8S255 - D8S268 /ANK1 - POLB /PLAT PLAT - cen - D8S531 /D8S519 - D8S517 /D8S538 - D8S524 - qter
Authors SCW8-1 (94)
Physical map
FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase FLJ25169 8p11.21 hypothetical protein FLJ25169 ANK1 8p11.2 ankyrin 1, erythrocytic MYST3 8p11 MYST histone acetyltransferase (monocytic leukemia) 3 AP3M2 8p11.2 adaptor-related protein complex 3, mu 2 subunit PLAT 8p12-p11.2 plasminogen activator, tissue LOC389650 8 LOC389650 IKBKB 8p11.2 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta POLB 8p11.2 polymerase (DNA directed), beta DKK4 8p11.2-p11.1 dickkopf homolog 4 (Xenopus laevis) VDAC3 8q11.2 voltage-dependent anion channel 3 SLC20A2 8p12-q21 solute carrier family 20 (phosphate transporter), member 2 LOC114926 8p11.21 hypothetical protein BC013035 CHRNB3 8p11.2 cholinergic receptor, nicotinic, beta polypeptide 3 CHRNA6 8p22 cholinergic receptor, nicotinic, alpha polypeptide 6 THAP1 8p11.1 THAP domain containing, apoptosis associated protein 1 DKFZP564A022 8p11.21 hypothetical protein DKFZp564A022 HOOK3 8p11.21 hook homolog 3 (Drosophila) FNTA 8p22-q11 farnesyltransferase, CAAX box, alpha FLJ23356 8p11.21 hypothetical protein FLJ23356 FLJ32731 8p11.1 hypothetical protein FLJ32731 LOC347028 8p11.21 similar to AFG3-like protein 2 (Paraplegin-like protein) LOC340441 8p11.21 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389651 8 similar to hypothetical protein (L1H 3 region) - human
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1259 - 335 - Sellick (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Creb1 binding site
  • HOMOLOGY
    Homologene
    FAMILY
  • DNA polymerase type-X family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in DNA repair and synthesis also having a DNA ligase activity
  • is required at a very early step in the processing of meiotic DSB
  • is required at a very early step in the processing of meiotic DSBs, at or before the removal of SPO11 from DSB ends and the generation of the 3prime single-stranded tails necessary for subsequent strand exchange
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, repair
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text involved in repair of oxidative base lesions
    PATHWAY
    metabolism
    signaling
    DNA repair pathways
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with XRCC1 (XRCC1-POLB interaction is important for repair of damage caused by alkylating agents)(Cuneo 2010)
  • is critical for the repair of SPO11-induced double-strand breaks (DSBs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is an underlying cause of systemic lupus erythematosus (SLE)
    Susceptibility
  • to gastric, colon, prostate carcinoma
  • Variant & Polymorphism other
  • variant increasing the risk of carcinoma
  • people who carry the rs3136797 germline SNP may be at an increased risk for cancer susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS