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FLASH GENE
Symbol PODXL2 contributors: mct - updated : 05-04-2020
HGNC name podocalyxin like 2
HGNC id 17936
Location 3q21.3      Physical location : 127.348.038 - 127.391.652
Genatlas name endoglycan, mucin
Synonym name
  • podocalyxin-like 2
  • endoglycan
    • Synonym symbol(s) EG
    DNA
    TYPE functioning gene
    STRUCTURE 43.62 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2175 - 605 - 2008 18606703
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Cardiovascularendothelial cell Homo sapiens
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunelymphocyte Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage multipotent,hematopoietic progenitors
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • extremely acidic N terminal region several potential glycosaminoglycan attachment site
  • share an identical C-terminal PDZ-binding motif (DTHL) with PODXL (
    • HOMOLOGY
    Homologene
    FAMILY
  • podocalyxin family of sialomucins
  • CD34 family
    • CATEGORY secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • inhibition of stem cell differentiation and leukocyte endothelial adhesion
  • can function as a ligand for the vascular selectins
  • enhance the trafficking and migration of hematopoietic cells (
  • appears to have a role in cell morphogenesis (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • implicated as a SELL ligand on endothelial cells, was present on human B cells, T cells and peripheral blood monocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS