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FLASH GENE
Symbol POC5 contributors: mct - updated : 01-04-2015
HGNC name POC5 centriolar protein
HGNC id 26658
Location 5q13.3      Physical location : 74.970.032 - 75.013.313
Synonym name centrosomal protein POC5
Synonym symbol(s) c5orf37
DNA
TYPE functioning gene
STRUCTURE 43.29 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1969 - 550 - -
12 - 2170 - 575 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text
  • localized, like centrin, in the distal portion of human centrioles
  • basic FUNCTION
  • not required for the initiation of procentriole assembly but is essential for building the distal half of centrioles
  • centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures that recruit other centrosomal proteins such as PCM1 and NEDD1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • centriole elongation requires POC5 and is restricted by CCP110 and CEP97
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to idiopathic scoliosis
    Variant & Polymorphism SNP
  • p.A446T variant was found associated to idiopathic scoliosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS