Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PNRC2 contributors: npt/ - updated : 06-07-2004
HGNC name proline-rich nuclear receptor coactivator 2
HGNC id 23158
Location 1p36.11      Physical location : 24.286.300 - 24.289.947
Synonym symbol(s) FLJ20312, MGC99541
DNA
TYPE functioning gene
STRUCTURE 3.60 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2428 - 139 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivefemale systembreastmammary gland  
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines non cancer breast cell line MCF-10A, breast cancer cell lines MCF-7, SK-BR-3 and MDA-MB-231
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential nuclear localization sequence
  • a SH3 binding motif
  • a NR box-like sequence (LKTLL), playing a role in the interaction with SF1 and ER-alpha
  • HOMOLOGY
    interspecies homolog to murine Pnrc2
    Homologene
    FAMILY
  • PNRC family
  • PNRC2 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope
    basic FUNCTION
  • acts as a coactivator through its interaction with proline-rich nuclear receptors such as SF1, ERR-alpha1, ERR-gamma, ER, GR, PR, TR, RAR and RXR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • nuclear receptors SF1, ERR-alpha, ER, GR, PR, TR, RAR and RXR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS