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FLASH GENE
Symbol PNPO contributors: mct/npt - updated : 09-01-2017
HGNC name pyridoxine-5'-phosphate oxidase
HGNC id 30260
Corresponding disease
NEE neonatal epileptic encephalopathy
Location 17q21.32      Physical location : 46.018.888 - 46.026.673
Synonym symbol(s) FLJ10535, PDXPO
EC.number 1.4.3.5
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 7.79 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site
text structure housekeeping genes, with a CpG island and Sp1 binding sites
MAPPING cloned Y linked N status provisional
Physical map
CDC27 17q21.3 cell division cycle 27 MYL4 17q21.2 myosin, light polypeptide 4, alkali; atrial, embryonic ITGB3 17q21.31 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3482 30 261 - 2014 24645144
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon  
 mouth   highly
Nervousbrainlimbic systemhippocampus  
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • pyridoxamine 5'-phosphate oxidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • catalyzes the terminal step in the synthesis of pyridoxal 5'-phosphate
  • oxidizing PNP and PMP into pyridoxal 5'-phosphate (PLP)
  • is one of a series of enzymes involved in converting pyridoxine to pyridoxal 5'-phosphate, the biologically active form of pyridoxine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FMN
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEE
    Susceptibility to schizophrenia in the Japanese population
    Variant & Polymorphism SNP increasing the risk of schizophrenia in the Japanese population
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS