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FLASH GENE
Symbol PNOC contributors: mct - updated : 12 -11-201
HGNC name prepronociceptin
HGNC id 9163
Location 8p21.1      Physical location : 28.174.648 - 28.200.866
Synonym name
  • orphanin FQ
  • nociceptin
  • nocistatin
  • Synonym symbol(s) PPNOC, NST, OFQ/N
    DNA
    TYPE functioning gene
    STRUCTURE 26.31 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1245 - 176 - 2006 16935438
    - - 1022 - 112 - 2006 16935438
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    Nervousbrain    
    Reproductivefemale systemovary  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six conserved cysteines
  • secondary structure
  • S-S bounds
  • HOMOLOGY
    interspecies homolog to murine Pnoc (82.39 pc)
    homolog to rattus Pnoc (78.41 pc)
    Homologene
    FAMILY belongs to the opioid neuropeptide precursor family
    CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
    text
  • secreted protein
  • basic FUNCTION
  • precursor of the natural agonist of opioid receptor-like receptor (OPRL1)
  • may act as a transmitter in the brain by modulating nociceptive and locomotor behavior
  • role in the control of GNRH1 secretion, raising the possibility that it acts as part of an ultrashort, autocrine feedback loop controlling GNRH1 pulses
  • may be involved in neuronal differentiation and development
  • may be involved in the autoregulation of peripheral blood mononuclear cells
  • endogenous opioid-like heptadecapeptide involved in many neurocognitive functions, including learning and memory
  • play a modulatory role throughout the body including nociceptive sensitivity, motor function, spatial learning, and the immune system
  • in addition to pain transmission, is involved in other central nervous functions such as learning and memory
  • is involved in several central nervous functions including pain transmission
  • is potentially a novel paracrine mediator of the FSH effects in the regulation of spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OPRL1
  • role of ERK-1/2 in the PNOC-induced inhibition of delayed rectifier potassium currents
  • activates nuclear factor kappa B
  • NIPSNAP1 s a nocistatin-interacting protein
  • cell & other
    REGULATION
    induced by
  • SP1
  • ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS