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FLASH GENE
Symbol PNMA2 contributors: mct - updated : 05-09-2018
HGNC name paraneoplastic antigen MA2
HGNC id 9159
Location 8p21.2      Physical location : 26.362.195 - 26.371.483
Synonym name
  • 40 kDa neuronal protein
  • paraneoplastic neuronal antigen MM2
  • retrotransposon gag domain containing 2
  • Synonym symbol(s) MA2, MM2, RGAG2, KIAA0883
    DNA
    TYPE functioning gene
    STRUCTURE 9.29 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4846 - 364 - 2016 27003254
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY PNMA family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a tumor antigen role
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PNMA2 functions as antagonist of MOAP1 and PNMA1 through heterodimeric interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high PNMA2 autoantibody titer in the blood of
  • small intestine neuroendocrine tumors patients
    is a sensitive and specific biomarker, superior to chromogranin A (CgA) for the risk of recurrence after radical operation of these tumors
    Therapy target
    ANIMAL & CELL MODELS