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FLASH GENE
Symbol PNMA1 contributors: mct - updated : 05-09-2018
HGNC name paraneoplastic antigen MA1
HGNC id 9158
Location 14q24.3      Physical location : 74.178.485 - 74.181.128
Synonym name
  • neuron- and testis-specific protein 1
  • 37 kDa neuronal protein
  • Synonym symbol(s) MA1
    DNA
    TYPE functioning gene
    STRUCTURE 2.64 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    WDR21 14q24.3 WD repeat domain 21 RPL36AP3 14 ribosomal protein L36a pseudogene 3 RPS12P1 14 ribosomal protein S12 pseudogene 1 ZFYVE1 14q22-q24 zinc finger, FYVE domain containing 1 RNPC7 14q24.3 RNA-binding region (RNP1, RRM) containing 7 PSEN1 14q24.3 presenilin 1 (Alzheimer disease 3) PAPLN 14q24.2 papilin, proteoglycan-like sulfated glycoprotein NUMB 14q24.3 numb homolog (Drosophila) C14orf169 14q24.2 chromosome 14 open reading frame 169 NT5CP2 14q24.2 5',3'-nucleotidase, cytosolic pseudogene 2 ZAP128 14q24.3 5',3'-nucleotidase, cytosolic pseudogene 2 NT5CP1 14q24.2 5',3'-nucleotidase, cytosolic pseudogene 1 PTE2B 14q24.2 peroxisomal acyl-CoA thioesterase 2B C14orf42 14q24.1 chromosome 14 open reading frame 42 NDUFB8P1 14 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, pseudogene 1 C14orf168 14q24.3 chromosome 14 open reading frame 168 PNMA1 14q24.2 paraneoplastic antigen MA1 ZADH1 14q24.1-q24.2 zinc binding alcohol dehydrogenase, domain containing 1 ZNF410 14q24.3 zinc finger protein 410 C14orf44 14q24.2 chromosome 14 open reading frame 44 COQ6 14q24.2 coenzyme Q6 homolog (yeast) ENTPD5 14q24 ectonucleoside triphosphate diphosphohydrolase 5 RPL41P4 14 ribosomal protein L41 pseudogene 4 C14orf45 14q24.2 chromosome 14 open reading frame 45 ALDH6A1 14q24.2 aldehyde dehydrogenase 6 family, member A1 C14orf46 14q24.2 chromosome 14 open reading frame 46 CHX10 14q24.3 ceh-10 homeo domain containing homolog (C. elegans) ABCD4 14q24.3 ATP-binding cassette, sub-family D (ALD), member 4 C14orf115 14q24.2 chromosome 14 open reading frame 115 RPS2P2 14 ribosomal protein S2 pseudogene 2 NPC2 14q24.3 Niemann-Pick disease, type C2 HBLD1 14q24.2 HESB like domain containing 1 C14orf141 14q24.2 chromosome 14 open reading frame 141 LTBP2 14q24.3 latent transforming growth factor beta binding protein 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2666 - 353 - 2016 27003254
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestiveintestinesmall intestine  moderately
     pancreas exocrine   highly
    Nervousbrain   predominantly Homo sapiens
    Reproductivefemale systemuterus  moderately
     male systemprostate  highly
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines in tumor cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Pnma1
    ortholog to murine Pnma1
    Homologene
    FAMILY PNMA family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text cytoplasmic in tumor cells
    basic FUNCTION
  • acting as a tumor antigen
  • is a proapoptotic protein in neurons, elevated expression of which may contribute to neurodegenerative disorders
  • is involved in tumor growth of pancreatic carcinoma and PNMA1-related pathways might represent a new treatment strategy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • central nervous system development
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MARK4
  • PARD3
  • PARD6B
  • PRKCI
  • PNMA2 functions as antagonist of MOAP1 and PNMA1 through heterodimeric interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS