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FLASH GENE
Symbol PMEPA1 contributors: mct - updated : 27-05-2011
HGNC name prostate transmembrane protein, androgen induced 1
HGNC id 14107
Location 20q13.31      Physical location : 56.223.453 - 56.286.541
Synonym name
  • open reading frame of the androgen-induced RNA
  • solid-tumor associated gene 1
  • transmembrane, prostate androgen induced RNA
  • Synonym symbol(s) TMEP, STAG1, TMEPAI
    DNA
    TYPE functioning gene
    STRUCTURE 63.09 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure
  • promoter is regulated synergistically by TGFB/SMAD and Wnt/beta-catenin/TCF7L2 (TCF7L2-binding element (TTE), is located in intron 1)
  • MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4930 31.6 287 - 2001 11568975
    4 - 4538 27.9 252 - 2001 11568975
    4 - 4531 26.2 237 - 2001 11568975
    4 - 4590 26.2 237 - 2001 11568975
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemprostate  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandular  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • type 1b transmembrane domain
  • PY motifs interacting with WW domains of NEDD4
  • HOMOLOGY
    intraspecies homolog to C180orf1
    Homologene
    FAMILY
  • TMEPAI family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in tumorigenesis
  • androgen-regulated NEDD4-binding protein, exhibiting cell growth inhibitory function
  • seems to act as a molecule involved in the negative feedback loop of TGFB signaling
  • transforming growth factor-beta (TGF-beta)-induced transmembrane protein that is overexpressed in several cancers
  • functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter
  • its functions depend on its SMAD2/3 binding motif
  • may promote AR-negative prostate cancer cell proliferation through CDKN1A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • PMEPA1-AR degradation pathway may represent a new androgen-dependent mechanism for regulating AR levels in prostate epithelial cells
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting NEDD4 (role in the ubiquitin-proteasome pathway)
  • direct transcriptional target of the androgen receptor (AR) (negatively regulates the stability of AR protein by enhancing AR ubiquitination and proteasome-mediated degradation through NEDD4)
  • can interact with either SMAD2 or SMAD3 via its SMAD interaction motif to sequester TGFB/SMAD signaling
  • cell & other
    REGULATION
    activated by synergistically transactivated by TGFB/SMAD and Wnt/beta-catenin/TCF7L2 at the transcriptional level
    induced by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer in progression
    tumoral     --over  
    in androgen-sensitive prostate tumor and in renal cell carcinoma
    tumoral     --over  
    in estrogen receptor/progesterone receptor-negative and epidermal growth factor receptor-2-negative breast cancer cell lines and primary breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS