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FLASH GENE
Symbol PLXNB3 contributors: mct - updated : 22-01-2014
HGNC name plexin B3
HGNC id 9105
Location Xq28      Physical location : 153.029.650 - 153.044.801
Synonym name plexin 6
Synonym symbol(s) PLXN6, PLEXR, PLEXB3
DNA
TYPE functioning gene
STRUCTURE 15.15 kb     36 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - DXS1193 - IDS /ABCD1 - AVPR2 - CXorf12 - EMD EMD - PLXNB3 - MPP1 - F8 - qter
Authors GeneMap
Physical map
LOC392559 X similar to hypothetical protein MGC15827 LOC139735 Xq28 similar to zinc finger protein 92 TREX2 Xq28 three prime repair exonuclease 2 LOC389904 X similar to Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2) BGN Xq28 biglycan ATP2B3 Xq28 ATPase, Ca++ transporting, plasma membrane 3 MGC29729 Xq28 hypothetical protein MGC29729 LOC340598 Xq28 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) DUSP9 Xq28 dual specificity phosphatase 9 LOC347544 Xq28 similar to ribosomal protein L18a; 60S ribosomal protein L18a MGC45419 Xq28 Similar to calcium/calmodulin-dependent protein kinase 1, beta SLC6A8 Xq28 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 BCAP31 Xq28 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 ABCD1 Xq28 ATP-binding cassette, sub-family D (ALD), member 1 PLXNB3 Xq28 plexin B3 STK23 Xq28 serine/threonine kinase 23 IDH3G Xq28 isocitrate dehydrogenase 3 (NAD+) gamma SSR4 Xq28 signal sequence receptor, delta (translocon-associated protein delta) KIAA1444 Xq28 LU1 protein HCP45 Xq28 cytochrome c, somatic pseudogene L1CAM Xq28 L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1) AVPR2 Xq28 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) ARHGAP4 Xq28 Rho GTPase activating protein 4 ARD1 Xq28 ARD1 homolog, N-acetyltransferase (S. cerevisiae) RENBP Xq28 renin binding protein HCFC1 Xq28 host cell factor C1 (VP16-accessory protein) CXorf12 Xq28 chromosome X open reading frame 12 IRAK1 Xq28 interleukin-1 receptor-associated kinase 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
37 - 6377 - 1932 - -
36 - 6211 - 1909 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
Nervousoligodendrocyte Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
from the N terminal a SEMA homology domain followed by three cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS,a single transmembrane segment (1TM)
HOMOLOGY
interspecies ortholog to murine Plxnb3
homolog to Drosophila plexB
homolog to C.elegans plx-2
Homologene
FAMILY calcium-dependent cell adhesion molecule family
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • highly potent stimulator of neurite outgrowth
  • may influence cognitive performance, and the development of white matter
  • SEMA5A and its receptor PLXNB3 play an important role in the invasion and metastasis of gastric carcinoma
  • under physiological conditions Plexin-B3 is not essential for the development and function of the central nervous system
  • SEMA5A and PLXNB3 impede motility but promote differentiation of human gliomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS