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FLASH GENE
Symbol PLXNA4 contributors: mct - updated : 30-08-2014
HGNC name plexin A4
HGNC id 9102
Location 7q32.3      Physical location : 131.808.091 - 132.333.447
Synonym name
  • plexin A4, A
  • plexin A4, B
  • Synonym symbol(s) PLEXA4, PLXNA4A, KIAA1550, FLJ38287, FLJ35026, DKFZp434G0625, DKFZp434G0625PRO34003, DKFZp566O0546, FAYV2820, PLXNA4B, PRO34003
    DNA
    TYPE functioning gene
    STRUCTURE 525.36 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3408 - 492 - -
    32 - 13061 212 1894 - -
    5 - 2020 - 522 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminal, a SEMA homology domain
  • three cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor for the semaphorin 7A (SEMA7A)
  • PLXNA3 and plexin-A4 are essential for normal sympathetic development
  • PLXNA3, PLXNA4 convey semaphorin signals during facial nerve development
  • PLXNA1, PLXNA4 are required simultaneously for transduction of inhibitory SEMA3A signals and that they form complexes
  • likely involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex
  • has a role in Alzheimer disease pathogenesis through isoform-specific effects on tau phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FARP1 serves as a specific effector of transmembrane SEMA6A and PLXNA4 signals to regulate lateral motor column (LMC) dendritic growth
  • receptor for SEMA6A and SEMA6B and associates with neuropilins to transduce signals of class-3 semaphorins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    combined loss of PLXNA3 and PLXNA4 impaired facial branchiomotor axon guidance more severely than loss of either plexin alone
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    may represent a target for the development of novel anti-angiogenic and anti-tumorigenic drugs
    ANIMAL & CELL MODELS