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FLASH GENE
Symbol PLXDC1 contributors: SGE - updated : 26-03-2010
HGNC name plexin domain containing 1
HGNC id 20945
Location 17q12      Physical location : 37.219.555 - 37.307.902
Synonym name
  • tumor endothelial marker 3
  • tumor endothelial marker 7
  • Synonym symbol(s) TEM3, TEM7, FLJ36270, FLJ45632, DKFZp686F0937
    DNA
    TYPE functioning gene
    STRUCTURE 88.35 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPL45 17q21.2 mitochondrial rbosomal protein L45 LOC342663 17q21.1 similar to mKIAA1136 protein NAP4 17q21.1 Nck, Ash and phospholipase C binding protein LOC388380 17 LOC388380 KIAA1501 17q21.1-q21.2 KIAA1501 protein KIAA1684 17q21.2 likely homolog of mouse p140 LOC390789 17 similar to RIKEN cDNA E130012A19 MLLT6 17q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 RNF110 12-12q22 ring finger protein 110 PSMB3 2q35 proteasome (prosome, macropain) subunit, beta type, 3 PIP5K2B 17q12 phosphatidylinositol-4-phosphate 5-kinase, type II, beta FLJ20291 17q21.2 hypothetical protein FLJ20291 LOC388381 17 LOC388381 RPL23 17q12 ribosomal protein L23 LASP1 17q12-q21 LIM and SH3 protein 1 LOC388382 17 hypothetical gene supported by BC009632; BC042124 FLJ43826 17q21.2 FLJ43826 protein PLXDC1 17q21.1 plexin domain containing 1 LOC390790 17 similar to Cg7197-prov protein CACNB1 17q21 calcium channel, voltage-dependent, beta 1 subunit RPL19 17q11 ribosomal protein L19 24b2/STAC2 17q21.2 24b2/STAC2 protein LOC388383 17 similar to upstream binding protein 1 MGC15482 17q21.2 F-box protein FBL2 PPARBP 17q12-q21.1 PPAR binding protein CRK7 17q21.2 CDC2-related protein kinase 7 NEUROD2 17p13.1 neurogenic differentiation 2 PPP1R1B 17q21.2 protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) STARD3 17q21.1 START domain containing 3 TCAP 17q12-q21.1 titin-cap (telethonin) PNMT 17q21.1 phenylethanolamine N-methyltransferase CAB2 17q21.2 CAB2 protein ERBB2 17q11.2-q12 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    RNA
    TRANSCRIPTS type messenger
    text produces four alternatively spliced transcripts with distinct functional domains (Halder 2009)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6271 - 500 - Carson-Walters (2001)
    precursor
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Nervousoptic nerve
    cell lineage
    cell lines endothelial cells from colorectal cancers and primary cancers of lung, liver, pancreas, breast and brain
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a plexin-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Plxdc1 (82.0pc)
    homolog to rattus Plxdc1 (82.6pc)
    Homologene
    FAMILY plexin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text secreted
    basic FUNCTION
  • having receptor activity
  • may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the fibrovascular membranes (Yamaji 2008)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    angiogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with corctactin CTTN (Nanda 2004)
  • interacting with nidogen (Lee 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in osteogenic sarcoma (Fuchs 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (Yamaji 2008)
  • elevated expression is associated with metastasis and poor survival of pateints with osteogenic sarcoma and may be a therapeutic target (Fuchs 2007)
  • ANIMAL & CELL MODELS