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FLASH GENE
Symbol PLSCR4 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 4
HGNC id 16497
Location 3q24      Physical location : 145.910.125 - 145.968.966
Synonym name
  • Ca(2+)-dependent phospholipid scramblase 4
  • cell growth-inhibiting gene 43 protein
  • PL scramblase 4
  • Synonym symbol(s) TRA1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with PLSCR1 and PLSCR2
    STRUCTURE 58.84 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365 GM2AP 3q21-q25 GM2 ganglioside activator protein pseudogene LOC389156 3 similar to 60S ribosomal protein L21 PLOD2 3q23-q24 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 PLSCR4 3q24 phospholipid scramblase 4 LOC389157 3 similar to CG32056-PA PLSCR2 3q24 phospholipid scramblase 2 PLSCR1 3q23 phospholipid scramblase 1 LOC389158 3 similar to Plscr1 protein ZIC4 3q24 Zic family member 4 ZIC1 3q24 Zic family member 1 (odd-paired homolog, Drosophila) LOC339899 3q24 hypothetical LOC339899 LOC391586 3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 LOC344741 3q24 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389159 3 LOC389159 RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3014 - 224 - -
    7 - 3042 36.9 239 - 2000 10930526
    9 - 3312 36.9 329 - 2000 10930526
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuterus    Homo sapiens
     male systemtestis   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple PXXP motifs
  • a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain-containing proteins
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in adjured, activated, or apoptotic cells
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in recognition of apoptotic and injured cells by the reticuloendothelial system
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • with PLSCR1, interact directly with the CD4 receptor at the cell surface of T lymphocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS