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FLASH GENE
Symbol PLSCR3 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 3
HGNC id 16495
Location 17p13.1      Physical location : 7.293.054 - 7.297.843
Synonym name
  • Ca(2+)-dependent phospholipid scramblase 3
  • PL scramblase 3
  • Synonym symbol(s) PLS3
    DNA
    TYPE functioning gene
    STRUCTURE 4.79 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DVL2 17p13.2 dishevelled, dsh homolog 2 (Drosophila) MGC2941 17p13.2 hypothetical protein MGC2941 GABARAP 17p13.1 GABA(A) receptor-associated protein DULLARD 17p13 dullard homolog (Xenopus laevis) DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1 KCTD11 17p13.2 potassium channel tetramerisation domain containing 11 LOC339168 17p13.2 hypothetical protein LOC339168 TNK1 17p13.1 tyrosine kinase, non-receptor, 1 PLSCR3 17p13.2 phospholipid scramblase 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1746 - 295 - 2000 10930526
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     liver    
    Endocrinepancreas    
    Reproductivefemale systemuterus    Homo sapiens
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple PXXP motifs
  • a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain containing proteins
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , PhosphoP , Other
    HOMOLOGY
    interspecies homolog to murine Plscr3
    homolog to C.elegans zk1053.5
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text
  • type II membrane protein
  • localized to mitochondria
  • basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in injured,activated or apoptotic cells
  • downstream effector of PRKCD in the mitochondria
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system
  • playing an analogous role in signaling and in the cellular response to insulin
  • novel regulator of cardiolipin de novo biosynthesis and its resynthesis
  • transports CL (cardiolipin) from the inner to the outer mitochondrial membrane
  • plays an important role in regulation of mitochondrial morphology, respiratory function, and apoptotic responses
  • playing a role in adipose lipid metabolism
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • its expression facilitates changes in mitochondrial membrane lipids that promote the release of apoptogenic factors and consequent full activation and processing of the caspase-9 and effector caspase-3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interaction with PRKCD (interacted with and phosphorylated phospholipid scramblase 3 (PLSCR3) after UV irradiation)
  • interacting with TNFSF10 (TNFSF10-induced activation of PKC-delta mediates regulation of the PLSCR3-induced changes in cardiolipin)
  • cell & other
    REGULATION
    Other phosphorylation by PRKCD induces PLSCR3 activation to facilitate mitochondrial targeting of BID and apoptosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS