Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLSCR2 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 2
HGNC id 16494
Location 3q24      Physical location : 146.151.081 - 146.213.722
Synonym name
  • Ca(2+)-dependent phospholipid scramblase 2
  • PL scramblase 2
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with PLSCR1 and PLSCR4
    STRUCTURE 62.64 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1265 25.5 224 - 2000 10930526
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • predominantly in the nucleus
  • basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in injured, activated or apoptotic cells
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS