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FLASH GENE
Symbol PLSCR2 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 2
HGNC id 16494
Location 3q24      Physical location : 146.151.081 - 146.213.722
Synonym name
  • Ca(2+)-dependent phospholipid scramblase 2
  • PL scramblase 2
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with PLSCR1 and PLSCR4
    STRUCTURE 62.64 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365 GM2AP 3q21-q25 GM2 ganglioside activator protein pseudogene LOC389156 3 similar to 60S ribosomal protein L21 PLOD2 3q23-q24 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 PLSCR4 3q24 phospholipid scramblase 4 LOC389157 3 similar to CG32056-PA PLSCR2 3q24 phospholipid scramblase 2 PLSCR1 3q23 phospholipid scramblase 1 LOC389158 3 similar to Plscr1 protein ZIC4 3q24 Zic family member 4 ZIC1 3q24 Zic family member 1 (odd-paired homolog, Drosophila) LOC339899 3q24 hypothetical LOC339899 LOC391586 3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 LOC344741 3q24 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389159 3 LOC389159 RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1265 25.5 224 - 2000 10930526
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • predominantly in the nucleus
  • basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in injured, activated or apoptotic cells
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS