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FLASH GENE
Symbol PLP2 contributors: mct - updated : 23-05-2016
HGNC name proteolipid protein 2 (colonic epithelium-enriched)
HGNC id 9087
Location Xp11.23      Physical location : 49.028.183 - 49.031.466
Synonym name
  • A4 differentiation dependent protein
  • intestinal membrane A4 protein
  • Synonym symbol(s) A4, A4-LSB, MGC126187
    DNA
    TYPE functioning gene
    STRUCTURE 3.29 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TIMM17B Xp11.23 translocase of inner mitochondrial membrane 17 homolog B (yeast) PQBP1 Xp11.3 polyglutamine binding protein 1 SLC35A2 Xp11.23-p11.22 solute carrier family 35 (UDP-galactose transporter), member A2 PIM2 Xp11.3-p11.2 pim-2 oncogene DKFZp761A052 Xp11.23 hypothetical protein DKFZp761A052 KCND1 Xp11.23 potassium voltage-gated channel, Shal-related subfamily, member 1 GRIPAP1 Xp11 GRIP1 associated protein 1 TFE3 Xp11.23-p11.22 transcription factor binding to IGHM enhancer 3 JM11 Xp11.23 JM11 protein JM4 Xp11.23 JM11 protein JM5 Xp11.23 JM5 protein T54 Xp11.23 T54 protein FLJ21687 Xp11.23 PDZ domain containing, X chromosome PLP2 Xp11.23 proteolipid protein 2 (colonic epithelium-enriched) LMO6 Xp11.23-p11.22 LIM domain only 6 SYP Xp11.23-p11.22 synaptophysin CACNA1F Xp11.23 calcium channel, voltage-dependent, alpha 1F subunit LOC347348 Xp11.23 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) JM1 Xp11.23 JM1 protein FOXP3 Xp11.23 forkhead box P3 PPP1R3F Xp11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3F LOC286408 Xp11.23 hypothetical LOC286408 LOC389855 X similar to G antigen 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1049 16 152 - 2014 24604726
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
     brainlimbic systemhippocampus   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Homo sapiens
    not specificgranular cell
    cell lineage
    cell lines differentially, in colonic epithelial cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments (4TM)
  • a MARVEL domain
  • conjugated GlycoP , LipoP
    mono polymer homomer , polymer
    HOMOLOGY
    interspecies homolog to rattus Plp2 (84.1 pc)
    homolog to murine Plp2 (80.1 pc)
    Homologene
    FAMILY
  • integral membrane protein (proteolipids) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • play a role in cell differentiation in the epithelium
  • acting as an ion transmembrane transporter
  • critical function to PLP2 for viral ligase activity
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • chemotaxis
  • cytokine and chemokine mediated signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLP2 (multimerize)
  • chemokine
  • physically interacting with CCT
  • CCR1
  • PLP2 binds specifically to PI3K, thus activating AKT1, and aids metastasis
  • PLP2 and RAB5C are novel TPD52 binding partners
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    directly promotes resistance to ER stressors
    Susceptibility to X-linked mental retardation (XLMR)
    Variant & Polymorphism SNP PLP2-(-113C>A) is sufficient to cause reduced expression and is enriched in a cohort of males with probable XLMR
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plp2-deficient mice show increased neuronal death to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model