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FLASH GENE
Symbol PLOD3 contributors: mct - updated : 20-06-2018
HGNC name procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
HGNC id 9083
Corresponding disease
SCDEDS2 spondylocheiro dysplastic form of the Ehlers-Danlos syndrome 2
Location 7q22.1      Physical location : 100.849.258 - 100.861.011
Synonym name lysyl hydroxylase, isoform 3
Synonym symbol(s) LH3
EC.number 1.14.11.4
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 11.75 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2995 82.4 738 - 2016 27435297
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas    
Lymphoid/Immunespleen   highly
Reproductivefemale systemovary  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal domain possessing trace amount of glycosyltransferase activity
  • a glycosyltransferase (GT/GGT) domain (25280), which is responsible for GT/GGT activities and has structural similarities with glycosyltransferases
  • a C terminal catalytic domain
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Plod3
    Homologene
    FAMILY
  • lysyl hydroxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • abundant PLOD3 localising to the basement membrane in normal skin
  • basic FUNCTION
  • catalyzing the hydroxylation of lysyl residues in collagenous sequences
  • multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and O-glycosylation of hydroxylysyl residues producing either monosaccharide (Gal) or disaccharide (Glc-Gal) derivatives
  • collagen galactosyltransferase activity (Risteli 2009)
  • is the multifunctional collagen-modifying enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and galactosylhydroxylysine-glucosyltransferase (GGT) activities
  • major function of PLOD3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen and impairment of this PLOD3 function significantly affects type I collagen fibrillogenesis
  • PLOD3 is an important regulator of adiponectin biosynthesis, secretion and activity
  • modulates cancer progression and metastasis
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FKBP10 forms complexes with PLOD2 splice variants LH2A and LH2B but not with PLOD1 and PLOD3
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
  • ascorbate
  • protein
  • modifies the lysine residues in the collagenous domain of adiponectin, which has important roles in glucose and lipid metabolism and inflammation
  • recruitment of MMP9 to the fibroblast cell surface occurs through its fibronectin-like (FN) domain and the molecule responsible for the recruitment is PLOD3
  • VIPAS39, with its partner proteins, regulate sorting of PLOD3 into newly identified post-Golgi collagen IV carriers and VIPAS39-dependent sorting is essential for modification of lysines in multiple collagen types
  • cell & other
    REGULATION
    Other regulation of post-Golgi PLOD3 trafficking is essential for collagen homeostasis and for the development and function of multiple organs and tissues
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDEDS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in glioma tissues compared to normal brain tissues, and correlated with negative survival
    constitutional       loss of function
    in Recessive dystrophic epidermolysis bullosa
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • might be a potential candidate for therapeutic applications in diseases associated with obesity and insulin resistance
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    is a potential therapeutic target in human gliomas
    ANIMAL & CELL MODELS