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FLASH GENE
Symbol PLK3 contributors: mct - updated : 08-10-2018
HGNC name polo-like kinase 3
HGNC id 2154
Location 1p34.1      Physical location : 45.266.035 - 45.271.666
Synonym name
  • polo-like kinase 3 (Drosophila)
  • cytokine-inducible kinase
  • FGF-inducible kinase
  • cytokine-inducible serine/threonine-protein kinase
  • proliferation-related kinase
  • Synonym symbol(s) FNK, PRK, CNK, PLK-3
    EC.number 2.7.11.21
    DNA
    TYPE functioning gene
    STRUCTURE 5.63 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2369 - 646 - 2002 12242661
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart    
    Digestiveliver   lowly
    Endocrinepancreas    
    Nervousbrain   lowly
    Reproductivefemale systemovary   
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, S, G2, M
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • polo box duplicated region
  • two polo box domains, a conserved Polo-box domain, shown to bind to phosphorylated Ser-pSer/pThr-Pro motifs
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae cdc25p
    ortholog to Drosophila melanogaster polo
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CDC5/Polo subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nuclear envelope
    text nuclear membrane at interphase, spindle poles and mitotic spindles throughout mitosis, midbody at telophase
    basic FUNCTION
  • serine/threonine protein kinase involved in regulating M phase functions
  • stress response protein that becomes phosphorylated following DNA damage or mitotic spindle disruption
  • may regulate entry into S phase in part through interaction with the phosphatase CDC25A, because its depletion also resulted in attenuation of cyclin E expression
  • its activation might cause cytoskeleton re-organization and result in growth suppression more pronouncedly in Ras pathway-activated cells
  • functions as an important regulator for cell proliferation and it suppresses tumorigenesis
  • new and essential player in the regulation of the hypoxia signaling pathway
  • essential component in the regulatory network of cell survival, angiogenesis, and hypoxic responses
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text
  • regulating the onset and/or progression of mitosis
  • dysregulated expression results in cell arrest and apoptosis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulating the dissociation of cohesin from chromosome in prophase
  • interacting with CIB1
  • topoisomerase IIalpha (TOP2A) is a novel physiological substrate for PLK3 and that PLK1 and PLK3 play different roles in cell-cycle regulation
  • is a negative regulator of HIF-1A stability
  • CIB1 is involved in regulating endomitosis, perhaps through its interaction with PLK3
  • cell & other
    REGULATION
    induced by hypoxic stress (hypoxia/reoxygenation induces PLK3 activation instead of the JNK effect to directly phosphorylate and activate JUN, subsequently contributing to apoptosis in corneal epithelial cells)
    Other cell cycle regulated,peak at S and G2 stages through perturbation of microtubule integrety
    regulated by TTP(tristetraprolin) (regulation of PLK3 mRNA stability by TTP may influence the control of the cell cycle by this protein kinase)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in synovial sarcoma after SYT-SSX inhibition
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    PLK3-/- mice develop tumors in multiple organs at an enhanced rate