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FLASH GENE
Symbol PLG contributors: mct - updated : 01-03-2017
HGNC name plasminogen
HGNC id 9071
Corresponding disease
PLG conjunctivitis, ligneous
TRDP thrombosis, recurrent, dysplasminogenemic type
Location 6q26      Physical location : 161.123.224 - 161.175.083
EC.number 3.4.21.7
DNA
TYPE functioning gene
STRUCTURE 51.86 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
LOC389440 6 LOC389440 LOC346064 6q25.3 similar to SNARE protein Ykt6; YKT6, S. cerevisiae, homolog of RSHL2 6q25.3 radial spokehead-like 2 TAGAP 6q25.3 T-cell activation GTPase activating protein LOC389441 6 LOC389441 LOC389442 6 LOC389442 LOC389443 6 LOC389443 LOC389444 6 similar to frazzled CG8581-PA FNDC1 6q25 fibronectin type III domain containing 1 LOC389445 6 similar to 60S ribosomal protein L21 SOD2 6q25.2 superoxide dismutase 2, mitochondrial WTAP 6q25-q27 Wilms tumor 1 associated protein ACAT2 6q25.3-q26 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) TCP1 6q25.1-q25.2 t-complex 1 MRPL18 6q25.3 mitochondrial ribosomal protein L18 PNLDC1 6q25.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 MAS1 6q25.3-q26 MAS1 oncogene IGF2R 6q26-q27 insulin-like growth factor 2 receptor SLC22A1 6q27 solute carrier family 22 (organic cation transporter), member 1 SLC22A2 6q26-q27 solute carrier family 22 (organic cation transporter), member 2 SLC22A3 6q26-q27 solute carrier family 22 (extraneuronal monoamine transporter), member 3 APOAL 6q26-q27 apolipoprotein A-like LPA 6q26-q27 lipoprotein, Lp(a) PLG 6q26 plasminogen LOC389446 6 similar to apolipoprotein(a) (EC 3.4.21.-) - rhesus macaque (fragment) LOC389447 6 LOC389447 MAP3K4 6q25.3 mitogen-activated protein kinase kinase kinase 4 AGPAT4 6q25.3 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) C6orf59 6q25.3 chromosome 6 open reading frame 59 PARK2 6q25.2-q27 Parkinson disease (autosomal recessive, juvenile) 2, parkin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 3538 - 810 - 2006 16478887
5 - 1200 - 136 - 2006 16478887
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen    
Nervousbraindiencephalonhypothalamus   Mus musculus
 brainforebraincerebral cortex   Mus musculus
 brainlimbic systemhippocampus   Mus musculus
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five cysteine-rich kringle domains
  • a protease domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • dissolving the fibrin of blood clots and acting as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling,
  • tumor invasion, and inflammation
  • is a protease that binds to the ECM and, upon conversion to plasmin, degrades multiple ECM proteins
  • Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous antiangiogenic agent
  • role of plasminogen activation in neuronal organization and survival
  • unanticipated role of PLG in the regulation of gene expression and cholesterol metabolism by macrophages and identify PLG-mediated regulation of leukotriene B4 as an underlying mechanism
  • is a critical factor of the tissue fibrinolytic system, which mediates tissue repair in the skin and liver
  • contributes to angiogenesis related to macrophage accumulation, TGFB1, and VEGFA, thereby leading to the enhancement of bone repair
  • has a role in airway inflammation
  • PLG-dependent proteolysis has a beneficial effect during neurological recovery after stroke, at least in part, by promoting axonal remodeling in the denervated spinal cord
  • may play an important role in innate immunity by changing expression of genes that contribute to phagocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLG regulates MMP9-dependent CXCR4 expression to facilitate hematopoietic progenitor and stem cell (HPSC) mobilization in response to CSF3
  • binding of ADAMTS13 to Lys-PLG may play an important role to localize these two proteases at sites of thrombus formation or vascular injury where the fibrinolytic system is activated
  • PLG-dependent CD36 expression and foam cell formation depended on conversion of PLG to plasmin, binding to the macrophage surface, and the consequent intracellular signaling that leads to production of leukotriene B4
  • PLG stimulates airway smooth muscle (ASM) cytokine production in a manner regulated by ANXA2
  • PLAT converts the zymogen plasminogen (PLG) into plasmin
  • PLG may regulate the DPP4 activity and the glucose metabolism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PLG , TRDP
    Susceptibility
  • to Giant Cell Arteritis (GCA)
  • to atherosclerosis and periodontitis
  • Variant & Polymorphism SNP
  • rs4252134 increasing the risk of GCA
  • risk alleles in the genes CDKN2B-AS1, CAMTA1 and PLG that are shared between coronary artery disease (CAD) and periodontitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plg deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis
  • Plg(-/-) mice display decreased bone mineral density
  • after induction of peritonitis by thioglycollate injection, we found that Plg(-/-) mice displayed diminished macrophage trans-ECM migration and decreased MMP9 activation