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FLASH GENE
Symbol PLEKHM3 contributors: mct/npt - updated : 20-04-2009
HGNC name pleckstrin homology domain containing, family M, member 3
HGNC id 34006
Location 2q33.3      Physical location : 208.686.011 - 208.890.284
Synonym name
  • differentiation associated protein
  • pleckstrin homology domain containing, family M, member 1-like
  • Synonym symbol(s) DAPR, FLJ41210, PLEKHM1L, DKFZp686O04200
    DNA
    TYPE functioning gene
    STRUCTURE 173.64 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 9807 87 761 - Virtanen (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PH domains, which are commonly associated with phosphoinositide binding and membrane targeting
  • a C1 binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • pleckstrin-like family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localized to the cytosol, migrating with AKT1 to the membrane after initiation of muscle differentiation (Virtanen 2009)
  • localized to the Golgi apparatus before differentiation (Virtanen 2009)
  • basic FUNCTION
  • key component required by myoblasts for orchestrating their differentiation during myogenesis (Virtanen 2009)
  • plays a role not just in muscle but in many other tissue types (Virtanen 2009)
  • acting as a scaffold protein for AKT1 (AKT1 is involved in a variety of cellular signaling processes, having directed action during muscle differentiation) (Virtanen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    involved in the PI3K signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the PI3K signaling pathway member protein kinase B (PKB) (Virtanen 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS