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FLASH GENE
Symbol PLEKHG6 contributors: mct/npt - updated : 29-01-2010
HGNC name pleckstrin homology domain containing, family G (with RhoGef domain) member 6
HGNC id 25562
Location 12p13.31      Physical location : 6.419.601 - 6.437.664
Synonym name myosin interacting guanine nucleotide exchange factor
Synonym symbol(s) FLJ10665, MGC126315, MGC126353, MGC126354, MyoGEF
DNA
TYPE functioning gene
STRUCTURE 18.07 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2981 - 790 - Wu (2009)
15 - 3149 - 758 - Wu (2009)
16 - 2899 - 790 - Wu (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text
  • with PLK1 colocalize at the spindle pole and central spindle during mitosis and cytokinesis (Asiedu 2008)
  • localizes to the central spindle and cleavage furrow
  • basic FUNCTION
  • role in regulating RHOA and RHOC activation as well as cell polarity and invasion in an invasive breast cancer (Wu 2009)
  • cooperates with MYH9 to regulate the polarity and invasion activity of breast cancer cells through activation of RHOA and RHOC (Wu 2009)
  • activates RHOA, and is required for cytokinesis (Asiedu 2008)
  • activates RhoG and to a much lesser extent RAC1 (D'Angelo 2007)
  • PLEKHG6 and ezrin are both required in macropinocytosis (D'Angelo 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with ezrin and RHOG (D'Angelo 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between ezrin and PLEKHG6 (ezrin recruits PLEKHG6 to the apical pole of epithelial cells where PLEKHG6 induces the formation of microvilli and membrane ruffles) (D'Angelo 2007)
  • interacts with MYH9 and exhibits activity toward RHOA (acting as a functional unit at the cleavage furrow to advance furrow ingression during cytokinesis) (Wu 2006)
  • interacts with centrosome/spindle pole-associated protein (CSPP), which is concentrated at the spindle pole and central spindle during mitosis and cytokinesis (C-terminus of PLEKHG6 and N-terminus of CSPP1 are required for their interaction)(PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS