basic FUNCTION
| apoptosis inducing protein |
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may launch caspase-independent apoptosis through the lysosomal-mitochondrial pathway |
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able to initiate caspase-independent apoptosis through lysosomal-mitochondrial apoptotic pathway |
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recruits phosphorylated TP53 to lysosomes and triggers lysosomal destabilization in apoptosis |
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by modulating the endosomal and/or lysosomal pathway, PLEKHF1 and PLEKHF2 may function as a membrane organizer that controls (at a cellular or subcellular level) the space and time of intracellular signal propagation |
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involved in caspase-independent apoptosis |
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modulates the membrane density of certain receptors and participates in endocytosis and autophagy processes |
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in addition to its role in endosome transport, also involved in lysosomal targeting and autophagosome formation |
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modulated the protein content of the plasma membrane and was involved in different endocytosis events |