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FLASH GENE
Symbol PLEKHB2 contributors: mct - updated : 20-11-2014
HGNC name pleckstrin homology domain containing, family B (evectins) member 2
HGNC id 19236
Location 2q21.1      Physical location : 131.862.419 - 131.907.424
Synonym name
  • evectin-2
  • Synonym symbol(s) EVT2, FLJ20783
    DNA
    TYPE functioning gene
    STRUCTURE 45.01 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4350 - 230 - 1999 10200314
    8 - 4347 - 229 - 1999 10200314
    9 - 4368 - 236 - 1999 10200314
    8 - 4326 - 222 - 1999 10200314
    9 - 4365 - 235 - 1999 10200314
    8 - 4323 - 221 - 1999 10200314
    7 - 4317 - 178 - 1999 10200314
    6 - 4196 - 171 - 1999 10200314
    6 - 4193 - 170 - 1999 10200314
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal pleckstrin homology (PH) domain, which can specifically bind phosphatidylserine, which is enriched in recycling endosomes, and plays an essential role in retrograde transport from recycling endosomes to the trans-Golgi network
  • a C-terminal hydrophobic region
  • HOMOLOGY
    interspecies homolog to murine Plekhb2
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text vesicular protein
    basic FUNCTION
  • may function as transport module for the directed import or assembly of protein or lipid into membranous organelles
  • recycling endosomal protein involved in retrograde transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to SMAP2, an Arf GTPase-activating protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS