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FLASH GENE
Symbol PLEKHB2 contributors: mct - updated : 20-11-2014
HGNC name pleckstrin homology domain containing, family B (evectins) member 2
HGNC id 19236
Location 2q21.1      Physical location : 131.862.419 - 131.907.424
Synonym name
  • evectin-2
  • Synonym symbol(s) EVT2, FLJ20783
    DNA
    TYPE functioning gene
    STRUCTURE 45.01 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC12981 2q21.2 hypothetical protein MGC12981 IMP4 2q21.2 U3 snoRNP protein 4 homolog PTPN18 2p14-q14.3 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) LOC391438 2 similar to hypothetical protein A230046P18 LOC391439 2 similar to hypothetical protein DKFZp434F1719 LOC389036 2 similar to FKSG30 LOC389037 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta CRYPTIC 2q21.1 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC391440 2 similar to testicular serine protease 1 LOC391441 2 similar to testicular serine protease 1 LOC391442 2 similar to FKSG30 DKFZp434F1719 LOC150519 2q21.2 similar to hypothetical protein A230046P18 GPR148 2q21.2 G protein-coupled receptor 148 FLJ38377 2q21.2 hypothetical protein FLJ38377 HCP8 2q21.1 cytochrome c, somatic pseudogene LOC389038 2 LOC389038 ARHGEF4 2q22 Rho guanine nucleotide exchange factor (GEF) 4 LOC389039 2 similar to CDNA sequence BC043098 PLEKHB2 2q22.1 pleckstrin homology domain containing, family B (evectins) member 2 LOC391443 2 similar to Serine/threonine-protein kinase Nek2 (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) LOC389040 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389041 2 similar to hypothetical protein A230046P18 LOC389042 2 similar to sequence-specific single-stranded-DNA-binding protein LOC150786 2q21.2 RAB6C, member RAS oncogene family pseudogene LOC389043 2 hypothetical gene supported by AK125982; BC042817 GNAQP 2q14.3-q21 quanine nucleotide binding protein (G protein), q polypeptide pseudogene LOC344228 2q21.2 similar to Hypothetical UPF0120 protein DKFZp564C186 LOC284988 2q21.2 similar to ARHQ protein H2-ALPHA 2q21.2 alpha-tubulin isotype H2-alpha LOC389045 2 similar to RIKEN cDNA 2610001E06 FLJ41352 2q21.2 FLJ41352 protein LOC90557 2q21.2 hypothetical protein BC016861 LOC389046 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389047 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC129439 2q21.2 similar to FKSG30 LOC391444 2 similar to mKIAA0767 protein LOC389048 2 LOC389048 AF038169 2q21.2 hypothetical protein AF038169 LOC389049 2 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) LOC389050 2 LOC389050 LOC389051 2 LOC389051 LOC163336 2q21.2 similar to FLJ10101 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4350 - 230 - 1999 10200314
    8 - 4347 - 229 - 1999 10200314
    9 - 4368 - 236 - 1999 10200314
    8 - 4326 - 222 - 1999 10200314
    9 - 4365 - 235 - 1999 10200314
    8 - 4323 - 221 - 1999 10200314
    7 - 4317 - 178 - 1999 10200314
    6 - 4196 - 171 - 1999 10200314
    6 - 4193 - 170 - 1999 10200314
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal pleckstrin homology (PH) domain, which can specifically bind phosphatidylserine, which is enriched in recycling endosomes, and plays an essential role in retrograde transport from recycling endosomes to the trans-Golgi network
  • a C-terminal hydrophobic region
  • HOMOLOGY
    interspecies homolog to murine Plekhb2
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text vesicular protein
    basic FUNCTION
  • may function as transport module for the directed import or assembly of protein or lipid into membranous organelles
  • recycling endosomal protein involved in retrograde transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to SMAP2, an Arf GTPase-activating protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS