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FLASH GENE
Symbol PLEKHA3 contributors: mct - updated : 19-09-2018
HGNC name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
HGNC id 14338
Location 2q31.2      Physical location : 179.345.198 - 179.369.780
Synonym name
  • four-phosphate-adaptor protein 1
  • phosphatidylinositol-four-phosphate adapter protein 1
  • Synonym symbol(s) FAPP1, FLJ20067
    DNA
    TYPE functioning gene
    STRUCTURE 35.87 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HOXD4 2q31 homeo box D4 HOXD3 2q31 homeo box D3 HOXD1 2q31-q37 homeo box D1 LOC150978 2q31.2 similar to 60S acidic ribosomal protein P1 LOC129841 2q31.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MTX2 2q24.3-q31 metaxin 2 LOC375295 2q31.2 hypothetical gene supported by BC013438 FUCA1P 2q31-q32 fucosidase, alpha-L- 1, tissue pseudogene LOC391465 2 similar to STIP1 homology and U-Box containing protein 1; serologically defined colon cancer antigen 7; carboxy terminus of Hsp70p-interacting protein; heat shock protein A binding protein 2 (c-terminal) LOC150739 2q31.2 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 hnRNPA3 2q31.2 heterogeneous nuclear ribonucleoprotein A3 NFE2L2 2q31 nuclear factor (erythroid-derived 2)-like 2 DKFZp451M2119 2q31.2-q31.3 hypothetical protein DKFZp451M2119 AGPS 2q33 alkylglycerone phosphate synthase FLJ30990 2q31.3 hypothetical protein FLJ30990 FLJ13946 2q31.3 hypothetical protein FLJ13946 PDE11A 2q31 phosphodiesterase 11A HCP9 2q31.2 cytochrome c, somatic pseudogene DRB1 2q31.3 developmentally regulated RNA-binding protein 1 OSBPL6 2q31-q32.1 oxysterol binding protein-like 6 PRKRA 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator NUDCP2 2q31 nuclear distribution gene C homolog (A. nidulans) pseudogene 2 FKBP7 2q31.2 FK506 binding protein 7 PLEKHA3 2q31.2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 TTN 2q24.3-q31 titin FLJ39502 2q31.3 hypothetical protein FLJ39502 DKFZp434O0515 FLJ25270 LOC389065 2 similar to RIKEN cDNA B830010L13 gene LOC391466 2 similar to dim1 KIAA1604 2q32.1 KIAA1604 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2516 - 300 - 2014 24462251
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
    Nervousbrain   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology (PH) domain, with a ARF1 binding site on PLEKHA3-PH distinct from a positively charged phosphatidylinositol-4-phosphate (PI4P) binding site
  • a proline-rich putative SH3-binding motif
  • HOMOLOGY
    interspecies homolog to murine Plekha3
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • is recruited to the Golgi through binding of its pleckstrin homology (PH) domain to phosphatidylinositol 4-phosphate (PtdIns(4)P) and a small GTPase ADP-ribosylation factor 1 (ARF1)
  • basic FUNCTION
  • effector of phosphatidylinositol 4 phosphate (PI4P)
  • component of the machinery regulated by PI4P and ADP-ribosylation factor (ARF) that controlsthe generation of post-Golgi carriers
  • PLEKHA3, PLEKHA8 are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    interacts with PI4P
    protein
  • interaction of PLEKHA3 with ARF1 and PI4P at a membrane surface
  • cell & other
    REGULATION
    Other PI4P and ARf regulate PLEKHA3-Golgi association
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS