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FLASH GENE
Symbol PLEKHA2 contributors: mct - updated : 18-09-2018
HGNC name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
HGNC id 14336
Location 8p11.22      Physical location : 38.758.752 - 38.831.428
Synonym name tandem PH Domain containing protein-2
Synonym symbol(s) TAPP2
DNA
TYPE functioning gene
STRUCTURE 72.68 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC392213 8 similar to SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; BAF57 LOC389647 8 LOC389647 LOC389648 8 LOC389648 FLJ14299 8p11.23 hypothetical protein FLJ14299 C8orf2 8p11.2 chromosome 8 open reading frame 2 PROSC 8p11.2 proline synthetase co-transcribed homolog (bacterial) GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase LOC169355 8p11.22 hypothetical protein LOC169355 C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 5656 - 425 - 2013 23460911
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/ImmuneB cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two pleckstrin homology (PH) domains
HOMOLOGY
Homologene
FAMILY
CATEGORY adaptor , protooncogene
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • may play roles in B and T cell activation
  • PLEKHA2 is a novel link between PI3K signaling and the cytoskeleton with potential relevance for leukemia progression
  • interaction of PLEKHA2, PLEKHA1 with PI(3,4)P2 mediates feedback inhibition impacting on BCR signaling, with functional significance for control of autoreactive B cells
  • PLEKHA2 function in cell migration is also apparent in the more complex context of B cell migration into stromal cell layers - a process that is only partially dependent on PI3K and CXCL12
  • regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration
  • serves as oncogenic gene in esophageal squamous cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    interacts with phosphatidylinositol 3,4 bisphosphate
    protein
  • binds MPDZ
  • binds PTPN13
  • DAPP1 and PLEKHA2 adaptors define a novel group of SHIP-activated targets of PI3K that regulate B cell Ag receptor signaling
  • PLEKHA2 is a novel link between PI3K signaling and the cytoskeleton with potential relevance for leukemia progression
  • binding of PLEKHA1 and PLEKHA2 adap-tors to PtdIns(3,4)P(2) function as negative regulators of the insulin and PI3K signalling pathways
  • PLEKHA1, PLEKHA2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K)
  • CXCL12-dependent migration of human malignant B cells requires both PI3K signaling and PLEKHA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary leukemic B cells that have strong migratory capacity
    tumoral     --over  
    in esophageal squamous cell carcinoma tissues compared with corresponding adjacent non-tumor tissues
    constitutional     --other  
    expressed in B-chronic lymphocytic leukemia (B-CLL) cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    may serve as a new target for ESCC therapy
    ANIMAL & CELL MODELS