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FLASH GENE
Symbol PLEK contributors: - updated : 29-08-2002
HGNC name pleckstrin
HGNC id 9070
Location 2p14      Physical location : 68.592.321 - 68.624.584
Synonym name platelet p47 protein
Synonym symbol(s) P47, FLJ27168
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - SLC1A4 - D2S290 - D2S134 - D2S282 - PLEK - D2S358 - qter
Authors Gene Map (98)
Physical map
MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 ETAA16 2p13-p15 ETAA16 protein LOC391382 2 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) C1D 2p13-p12 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) LOC116143 2p13.3 hypothetical protein BC014022 LOC56902 2p13.3 putatative 28 kDa protein PPP3R1 2p16-p15 protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) DKFZP566K1924 2p13.3 DKFZP566K1924 protein PLEK 2p14 pleckstrin LOC391383 2 similar to WD repeat domain 4 protein; WD repeat-containing protein 4 MGC47799 LOC391384 2 similar to KIAA0779 protein GPR73 2p14-p13.1 G protein-coupled receptor 73 KIAA0053 2p13.3 G protein-coupled receptor 73 BMP10 2p13.3 bone morphogenetic protein 10 LOC391385 2 similar to 18 kDa antrum mucosa protein; BRICHOS domain containing 1 GDDR 2p13.3 down-regulated in gastric cancer GDDR GKN1 2p13.3 gastrokine 1 ANTXR1 2p13.1 anthrax toxin receptor 1 GFPT1 2p13 glutamine-fructose-6-phosphate transaminase 1 HIRIP5 2p12 HIRA interacting protein 5 LOC388957 2 similar to expressed sequence C79663 LOC388958 2 hypothetical gene supported by AF090101 AAK1 2p24.3-p14 AP2 associated kinase 1 ANXA4 2p13 annexin A4 FLJ13057 2p13.3 hypothetical protein FLJ13057 similar to germ cell-less RY1 2p13.3 putative nucleic acid binding protein RY-1 MAD 2p12 MAX dimerization protein 1 FLJ25084 2p13.3 hypothetical protein FLJ25084 PCBP1 2p13-p12 poly(rC) binding protein 1 LOC151518 2p13.3 hypothetical LOC151518 MRPL36P1 2p13.2 hypothetical LOC151518 FLJ20558 2p13.3 hypothetical protein FLJ20558 TIA1 2p13 TIA1 cytotoxic granule-associated RNA binding protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 tonsils    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion lymph, blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential Ca2+ binding EF hand structure and a region that strongly resembles a PKC phosphorylation site, named the pleckstrin homology domain (PH),component of a DEP domain (Dishevelled/Egl-10-PH)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION platelet and leukocyte major protein C kinase substrate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS