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FLASH GENE
Symbol PLCZ1 contributors: - updated : 30-06-2004
HGNC name phospholipase C, zeta 1
HGNC id 19218
Location 12p13.31      Physical location : 18.836.115 - 18.890.918
Synonym name
  • PI-phospholipase C zeta 1
  • testis-development related NYD-SP27
    • Synonym symbol(s) NYD-SP27
    DNA
    TYPE functioning gene
    STRUCTURE 54.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CGI-26 12p13.1 CGI-26 protein UNRIP 12q11-q12 CGI-26 protein MGST1 12p1.2-p13.1 microsomal glutathione S-transferase 1 LOC338819 12p13.1 similar to chromatin-specific transcription elongation factor large subunit LOC121520 12p13.1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) DAT1 12p13.1 neuronal specific transcription factor DAT1 LOC283425 12p12.3 similar to S-phase kinase-associated protein 1A isoform a; organ of Corti protein 2; transcription elongation factor B (SIII), polypeptide 1-like; RNA polymerase II elongation factor-like protein OCP2; cyclin A/CDK2-associated p19 LOC387845 12 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC390297 12 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC390298 12 similar to Mitochondrial import inner membrane translocase subunit TIM17 B (JM3) FLJ22655 12p12.3 hypothetical protein FLJ22655 PIK3C2G 12p12 phosphoinositide-3-kinase, class 2, gamma polypeptide LOC160313 12q22 keratin 19 pseudogene PLCZ1 12p13.31 phospholipase C, zeta 1 CAPPA3 LOC90193 12p12.3 similar to ribosomal protein L7 PEPP2 12p12 phosphoinositol 3-phosphate-binding protein-2 AEBP2 12p12.3 AE(adipocyte enhancer)-binding protein 2 LOC341473 12p12.3 similar to T-complex protein 1, alpha subunit (TCP-1-alpha) (CCT-alpha) PDE3A 12p12 phosphodiesterase 3A, cGMP-inhibited SLCO1C1 12p12.3 solute carrier organic anion transporter family, member 1C1 SLCO1B3 12p12 solute carrier organic anion transporter family, member 1B3 LST-3 12p12.3 liver-specific organic anion transporter 3 SLCO1B1 12p solute carrier organic anion transporter family, member 1B1 SLCO1A2 12p12 solute carrier organic anion transporter family, member 1A2 IAPP 12p12.3-p12.2 islet amyloid polypeptide FLJ22028 12p12.3 hypothetical protein FLJ22028 RECQL 12p12-p11 RecQ protein-like (DNA helicase Q1-like) CGI-141 12p12.3 CGI-141 protein
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal EF-hand motif
  • central X and Y catalytic domains
  • a C terminal C2 domain
    • HOMOLOGY
    interspecies homolog to murine Plcz1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • phosphoinositide phospholipase C activity
  • may be the molecular trigger for egg activation during fertilization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Ca2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS