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FLASH GENE
Symbol PLCH2 contributors: mct - updated : 04-05-2021
HGNC name phospholipase C, eta 2
HGNC id 29037
Location 1p36.32      Physical location : 2.407.753 - 2.436.964
Synonym name
  • related to chain precursor of collagen IV alpha 4,50kDa
  • phospholipase C-like 4
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2
  • Synonym symbol(s) FLJ00417, KIAA0450, PLC-eta2, PLCL4, PLCeta2, RP3-395M20.1, PLCL4
    EC.number 3.1.4.11
    DNA
    TYPE functioning gene
    STRUCTURE 93.05 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4870 - 1416 - 2008 18361507
    22 - 5464 - 1129 - 2008 18361507
    22 - 5829 - 1019 - 2008 18361507
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbraindiencephalonepithalamushabenulahighly Homo sapiensAdult
     nervecranial nerve   
    Respiratorylung    
    Urinarykidney    
    Visualeyeretina  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualamacrine cell Homo sapiens
    Visualbipolar cell Homo sapiens
    Visualcone photoreceptor Homo sapiens
    Visualhorizontal association cell Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2 domain not responsible for Ca(2+) activation
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    intraspecies homolog to chain precursor of collagen IV alpha 4
    Homologene
    FAMILY
  • phosphoinositide-specific phospholipase C (PLC) superfamily
  • the PLC-eta family
  • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • likely involved in signal transduction pathways (Stewart 2005)
  • phosphoinositide phospholipase C activity activated by G protein beta-1-gamma-2 dimers (Zhou 2005)
  • likely importance of PLCH2 in the formation and maintenance of the neuronal network in the postnatal brain
  • exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina
  • may be involved in the function of habenula and retina
  • importance of the PLCH2 EF-hand domain and articulation of PLCH2 with LIMK1 in regulating neuritogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • PLCH2 specifically interacts with LIMK1 in Neuro2A cells
  • cell & other
    REGULATION
    activated by elevated intracellular Ca(2+) levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male age infertility
    Variant & Polymorphism other
  • age-related sperm differential methylation that accounted for 64 p100 of the effect of male age on lower fertilization rate
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS