Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLCH2 contributors: - updated : 22-11-2006
HGNC name phospholipase C, eta 2
HGNC id 29037
Location 1p36.32      Physical location : 2.407.753 - 2.436.964
Synonym name
  • related to chain precursor of collagen IV alpha 4,50kDa
  • phospholipase C-like 4
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2
  • Synonym symbol(s) FLJ00417, KIAA0450, PLC-eta2, PLCL4, PLCeta2, RP3-395M20.1, PLCL4
    EC.number 3.1.4.11
    DNA
    TYPE functioning gene
    STRUCTURE 29.21 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4837 - 1416 - Stewart (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
     pancreas    
    Nervousnervecranial nerve   
    Respiratorylung    
    Urinarykidney    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2 domain
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    intraspecies homolog to chain precursor of collagen IV alpha 4
    Homologene
    FAMILY
  • phosphoinositide-specific phospholipase C (PLC) superfamily
  • the PLC-eta family
  • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • likely involved in signal transduction pathways (Stewart 2005)
  • phosphoinositide phospholipase C activity activated by G protein beta-1-gamma-2 dimers (Zhou 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS