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FLASH GENE
Symbol PLCG2 contributors: mct/npt/pgu - updated : 24-05-2018
HGNC name phospholipase C, gamma 2 (phosphatidylinositol-specific)
HGNC id 9066
Corresponding disease
PLAID PLCG2-associated antibody deficiency and immune dysregulation
Location 16q24.1      Physical location : 81.812.929 - 81.991.898
Synonym name phosphoinositide phospholipase C
Synonym symbol(s) PLC-IV
EC.number 3.1.4.11
DNA
TYPE functioning gene
STRUCTURE 178.97 kb     33 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
33 - 4263 - 1265 - 2008 18728011
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two SH2 domains
  • one SH3
  • two pleckstrin homology (PH) domains (pleckstrin homology (PH) domain, designated as the split PH domain (spPH), is both necessary and sufficient to effect activation of PLCG2 by Rac2)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • phospholipase C, gamma 2, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • couple immune recognition receptors to important calcium- and protein kinase C-dependent cellular functions
  • responsible for ligand-mediated signaling in cells of the hematopoietic system, and playing a key role in the regulation of immune responses
  • critical regulatory role in various immune and inflammatory pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for parkin (PARK2 deficiency disrupts calcium homeostasis by modulating phospholipase C2 signalling)
  • directly binds to RAC2 (activated by Rac2)
  • TNFRSF11A-FAM102A signaling complex is necessary for PLCG2 phosphorylation that is required for the induction of NFATC1
  • molecular switch PLCG2 interacts with BANK1 and that the interaction is promoted by B-cell receptor (BCR) stimulation
  • kinase activity of BLK enhanced BANK1- PLCG2 binding and the interaction was suppressed upon BLK depletion
  • BCNP1 promotes BCR signaling by modulating the phosphorylation of BLNK, SYK, and PLCG2
    • cell & other
    REGULATION
    activated by markedly activated in intact cells by constitutively active Rac1(G12V), Rac2(G12V), and Rac3(G12V) but not by Cdc42(G12V) and RhoA(G14V)
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plcg2-null mice exhibit increased perinatal lethality with gastrointestinal hemorrhages