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FLASH GENE
Symbol PLCD4 contributors: mct - updated : 15-09-2006
HGNC name phospholipase C, delta 4
HGNC id 9062
Location 2q35      Physical location : 219.472.631 - 219.501.904
Synonym symbol(s) MGC12837
EC.number 3.1.4.3
DNA
TYPE functioning gene
STRUCTURE 29.27 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • TATA-less promoter with very GC-rich sequences near the transcription start site (Chae 2007)
  • a core promoter region with a factor binding sites responsible for the promoter activity (Chae 2007)
  • MAPPING cloned Y linked   status confirmed
    Physical map
    FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750 SLC11A1 2q35 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 CTDSP1 2q35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 VIL1 2q35 villin 1 USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39) CRYBA2 2q34-q36 crystallin, beta A2 DKFZp434O0527 2q36.1 hypothetical protein DKFZp434O0527
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3107 - - - Chae (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology (PH) domain, not a critical determinant of the localization of this protein, and does not act as a localization signal (Lee 2004)
  • 1 C2 domain
  • an EF-hand domain
  • a PI-PLC x-box domain
  • a PI-PLC y-box domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS