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FLASH GENE
Symbol PLCD3 contributors: - updated : 28-03-2006
HGNC name phospholipase C, delta 3
HGNC id 9061
Location 17q21      Physical location : 43.189.008 - 43.209.891
Synonym symbol(s) KIAA1964
EC.number 3.1.4.3
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure putative cAMP response element in the 5'-end promoter region
MAPPING cloned Y linked   status confirmed
Physical map
RPIP8 17p13.2 corticotropin releasing hormone receptor 1 CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein FZD2 17q21.1 frizzled homolog 2 (Drosophila) FLJ35848 17q21.31 hypothetical protein FLJ35848 FLJ31795 17q21.31 hypothetical protein FLJ31795 DRF1 17q21.31 Dbf4-related factor 1 ADAM11 17q21.3 a disintegrin and metalloproteinase domain 11 GJA7 17q21.31 gap junction protein, alpha 7, 45kDa (connexin 45) CLST11240 17q21.31 CLST 11240 protein U5-116KD 17q21.31 U5 snRNP-specific protein, 116 kD LOC388389 17 similar to RIKEN cDNA 4933439F11 GFAP 17q21.1 glial fibrillary acidic protein LOC146909 17q21.31 hypothetical protein LOC146909 CRF 17q21 C1q-related factor FLJ22955 17q21.31 hypothetical protein FLJ22955 NMT1 17q21.32 N-myristoyltransferase 1 PLCD3 17q21 phospholipase C, delta 3 ACBD4 17q21.31 acyl-Coenzyme A binding domain containing 4 HIS1 17q21.1 acyl-Coenzyme A binding domain containing 4 FLJ32384 17q21.31 hypothetical protein MGC39389 FMNL1 17q21 formin-like 1 FLJ25414 17q21.31 hypothetical protein FLJ25414 MAP3K14 17q21 mitogen-activated protein kinase kinase kinase 14 LOC388390 17 LOC388390 LOC201176 17q21.31 similar to Rho GTPase activating protein 12 LOC201175 17q21.31 hypothetical protein LOC201175 KIAA0356 17q21.1-q23.2 hypothetical protein LOC201175 FLJ10120 17q21.31 hypothetical protein FLJ10120 LOC388391 17 similar to KIAA0563 protein LOC339193 17q21.31 similar to dead end homolog 1; dead end protein FLJ25168 17q21.31 hypothetical protein FLJ25168 CRHR1 17q12-q22 corticotropin releasing hormone receptor 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
 female systemuteruscervix highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
c2 domain.
  • two EF-hand domains
  • a PH domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • phospholipase C, delta 3, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 3 calcium ions per subunit( two of the calcium ions are bound to the C2 domain)
    protein
    cell & other
    REGULATION
    inhibited by by cAMP and calcium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS