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FLASH GENE
Symbol PLCD3 contributors: - updated : 28-03-2006
HGNC name phospholipase C, delta 3
HGNC id 9061
Location 17q21      Physical location : 43.189.008 - 43.209.891
Synonym symbol(s) KIAA1964
EC.number 3.1.4.3
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure putative cAMP response element in the 5'-end promoter region
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
 female systemuteruscervix highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
c2 domain.
  • two EF-hand domains
  • a PH domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • phospholipase C, delta 3, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 3 calcium ions per subunit( two of the calcium ions are bound to the C2 domain)
    protein
    cell & other
    REGULATION
    inhibited by by cAMP and calcium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS