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FLASH GENE
Symbol PLCB3 contributors: mct - updated : 11-07-2015
HGNC name phospholipase C, beta 3 (phosphatidylinositol-specific)
HGNC id 9056
Location 11q13.1      Physical location : 64.018.994 - 64.036.924
Synonym name
  • PLC-beta-3
  • phosphoinositide phospholipase C-beta-3
    • Synonym symbol(s) PIP3
    EC.number 3.1.4.11
    DNA
    TYPE functioning gene
    STRUCTURE 17.93 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 5728 - 1234 - 2007 17675482
    29 - 5527 - 1167 - 2007 17675482
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systemuterus   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one C2 domain
  • myosin tail
  • a calmodulin binding site in the N-terminus
  • distal C-terminal domain forms an extended monomeric helical bundle consisting of three antiparallel segments with structural similarity to membrane-binding bin-amphiphysin-Rvs (BAR) domains, having roles in membrane targeting
    • HOMOLOGY
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • playing an important role in initiating receptor-mediated signal transduction
  • mediating a wide variety of cellular stimuli, inducing tumor suppresion of neuroendocrine tumor cell lines
  • involved in axon specification, possibly by stimulating neurite outgrowth
  • PLCB2, PLCB3 play a critical role in T lymphocyte chemotaxis
  • role in VEGFA-mediated directional migration and vascular sprouting
  • key modulator of IL8 expression in cystic fibrosis bronchial epithelial cells
  • mediator of LH-induced differentiation responses of granulosa cells
  • role of PLCB3 as a negative regulator of VEGFA-mediated vascular permeability by regulating intracellular Ca2+ release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form the multimolecular SPS complex together with PTPN6 and STAT5
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSH3 (activation of)
  • interacting with calmodulin
  • LYN/PLCB3-mediated regulatory mechanism of PTPN6 and STAT5B activities
  • interaction with STAT5B and PTPN6 (PLCB3-C-terminus is the STAT5B- and PTPN6-binding domain having a potential utility in the control of hematopoietic malignancies)
  • ARF6 is an important mediator of cytoskeleton and cell motility, which is regulated by PLCB3-dependent membrane translocation of the guanine nucleotide exchange factors (GEFs)
  • direct interaction between CHRM3 and PLCB3
  • PLCB3, INPP5J interact with N-terminus region of TRPM4 channel
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in neuroendoctrine tumor
    constitutional       loss of function
    loss of PLCB2 and PLCB3 significantly impaired T cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plcb3-deficient mice develop myeloproliferative neoplasm, like Lyn (Src family kinase)- deficient mice