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FLASH GENE
Symbol PLAGL2 contributors: mct/npt - updated : 28-05-2010
HGNC name pleiomorphic adenoma gene-like 2
HGNC id 9047
Location 20q11.21      Physical location : 30.780.306 - 30.795.546
Synonym name
  • Xenopus finger protein homolog
  • C2H2-type zinc finger protein
  • pleiomorphic adenoma-like protein 2
  • Synonym symbol(s) KIAA0198, FLJ23283
    DNA
    TYPE functioning gene
    STRUCTURE 15.24 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391241 20 similar to Soggy-1 protein precursor (SGY-1) LOC149935 20q11.21 similar to CDK5 regulatory subunit associated protein 3; CDK5 activator-binding protein C53; ischemic heart CDK5 activator-binding protein C53 RPL31P3 20p11-q11 ribosomal protein L31 pseudogene 3 DEFB118 20q11.1-q11.22 defensin, beta 118 DEFB119 20q11.1 defensin, beta 119 DEFB123 20q11.1 defensin, beta 123 REM 20q11.1 RAS (RAD and GEM)-like GTP-binding LOC388794 20 similar to dJ1093G12.6 (A novel protein) HM13 20q11.21 histocompatibility (minor) 13 ID1 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein COX4I2 20q11.21 cytochrome c oxidase subunit IV isoform 2 BCL2L1 20q11.1 BCL2-like 1 TPX2 20q11.2 TPX2, microtubule-associated protein homolog (Xenopus laevis) MYLK2 20q13.31 myosin light chain kinase 2, skeletal muscle FKHL18 20q11.1-q11.2 forkhead-like 18 (Drosophila) DUSP15 20 dual specificity phosphatase-like 15 LOC164395 20q11.21 hypothetical protein LOC164395 C20orf126 20q11.21 chromosome 20 open reading frame 126 LOC343702 20q11.21 similar to dJ310O13.4 (novel protein similar to predicted C. elegans and C. intestinalis proteins) C20orf160 20q11.2 chromosome 20 open reading frame 160 HCK 20q11.21 hemopoietic cell kinase TM9SF4 20q11.21 transmembrane 9 superfamily protein member 4 RPL24P1 20q11 ribosomal protein L24 pseudogene 1 TSPYL3 20q11.1 TSPY-like 3 PLAGL2 20q11.1 pleiomorphic adenoma gene-like 2 POFUT1 20q11 protein O-fucosyltransferase 1 KIF3B 20p11.2-q11.21 kinesin family member 3B ASXL1 20q11 additional sex combs like 1 (Drosophila) DKFZP566G1424 20q11.1-q11.23 hypothetical protein DKFZp566G1424 C20orf112 20q11.1-q11.23 chromosome 20 open reading frame 112 LOC284804 20q11.21 hypothetical protein LOC284804 LOC149950 20q11.21 hypothetical LOC149950 FLJ33706 20q11.22 hypothetical protein FLJ33706 C20orf92 20q11.22 chromosome 20 open reading frame 92 DNMT3B 20q11.2 DNA (cytosine-5-)-methyltransferase 3 beta MAPRE1 20q11.1-q11.23 microtubule-associated protein, RP/EB family, member 1 LOC388795 20 similar to hypothetical protein FLJ33620 SPAG4L 20q11.21 sperm associated antigen 4-like BPIL1 20q11.21 bactericidal/permeability-increasing protein-like 1 BPIL3 20q11.22 bactericidal/permeability-increasing protein-like 3 LOC391242 20 similar to DNA segment, numerous copies, expressed probes (GS1 gene) C20orf185 20q11.21 chromosome 20 open reading frame 185 C20orf186 20q11.21 chromosome 20 open reading frame 186
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5656 - 496 - Guo (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     mouthtongue  highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, liver, lung, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signal (NLS)located in the N-terminal domain with six C2H2 zinc fingers
  • an activation domain in the C-terminus (Wezensky 2010)
  • HOMOLOGY
    interspecies homolog to murine Plagl2
    intraspecies homolog to PLAG1
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having transcription factor activity and functioning as a tumor suppressor in association with HIF1A
  • may be an oxidative stress responding regulator in lung cells
  • controls the stability of RCHY1, an E3 ubiquitin ligase for TP53
  • transcription factor of the surfactant protein C (SP-C) promoter (Yang 2009)
  • having a pathogenic role in pulmonary emphysema, a critical aspect of severe chronic obstructive pulmonary disease (Yang 2009)
  • regulate the pro-apoptotic factor, BNIP3, demonstrating that PLAGL2 may also function as a tumor suppressor (Wezensky 2010)
  • plays a role in the regulation of NCF2, the gene encoding the NADPH oxidase cytosolic protein NCF2, but not sufficient to activate an NCF2 promoter-reporter plasmid, suggesting the requirement for other factors (Wezensky 2010)
  • with MED15, and SPI1 cooperate to enhance NCF2 promoter-reporter activity (Wezensky 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • with HIF1A
  • interacting with UBE2I (functioned as a co-factor of PLAGL2 on the surfactant protein-C promoter and the co-activation was independent of its SUMOylation enzymatic activity)
  • direct binding of PLAGL2 to the NCF2 promoter sequence (Wezensky 2010)
  • interaction between PLAGL2 and MED15 (Wezensky 2010)
  • cell & other
    REGULATION
    Other post-translationally modified by small ubiquitin-like modifier (SUMO), known as SUMOylation, and by acetylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia, with chromosome 16 inversion
    constitutional     --over  
    in alveolar epithelial cells correlated with the development of emphysema in the lung of chronic obstructive pulmonary disease patients (Yang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS